Results 201 to 210 of about 1,893,963 (378)

Pain Medicine: A Contemporary Perspective on Environmental Analysis and Strategic Planning [PDF]

, 2003
Melvin C. Gitlin
openalex   +1 more source

Double Cross‐Linked Hydrogel for Intra‐articular Injection as Modality for Macrophages Metabolic Reprogramming and Therapy of Rheumatoid Arthritis

Advanced Functional Materials, EarlyView.
A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song, Valentin A. Milichko, Ziqiao Ding, Wen Li, Bei Kang, Yunsheng Dou, Sona Krizkova, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

Faces of Experimental Pain: Transferability of Deep Learned Heat Pain Features to Electrical Pain [PDF]

arXiv
The limited size of pain datasets are a challenge in developing robust deep learning models for pain recognition. Transfer learning approaches are often employed in these scenarios. In this study, we investigate whether deep learned feature representation for one type of experimentally induced pain can be transferred to another.
arxiv  

Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease

Advanced Healthcare Materials, EarlyView.
The challenges of studying inflammatory bowel disease (IBD), highlighting limitations of traditional 2D cell cultures and animal models are discussed here. It introduces human intestine organ‐on‐chip (OoC) models as a promising alternative, capable of more accurately mimicking the intestinal microenvironment.
Tim Kaden, Raquel Alonso‐Román, Johannes Stallhofer, Mark S. Gresnigt, Bernhard Hube, Alexander S. Mosig   +5 more
wiley   +1 more source

Interventional Pain Medicine in the New Millennium

, 2000
Bert Fellows
openalex   +1 more source

Self-Management and Self-Management Support on Chronic Low Back Patients in Primary Care

, 2013
Chronic low back pain (CLBP) afflicts 28.5% of adults costing $100-200 billion dollars. In response, the Institute of Medicine (2011) strongly recommended self-management (SM) to engage patients to care for themselves adequately. Healthcare professionals
Kawi, Jennifer
core  

Controlled Release of Human Dental Pulp Stem Cell‐Derived Exosomes from Hydrogels Attenuates Temporomandibular Joint Osteoarthritis

Advanced Healthcare Materials, EarlyView.
Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia, Yajing Tian, Yunzhe Guo, Jiaying Li, Shengjie Cui, Cécile A. Dreiss, Eileen Gentleman, Xuedong Wang   +7 more
wiley   +1 more source

Supercritical Fluid‐Processed Multifunctional Hybrid Decellularized Extracellular Matrix with Chitosan Hydrogel for Improving Photoaged Dermis Microenvironment

Advanced Healthcare Materials, EarlyView.
These findings advance tissue repair by offering a multifunctional filler that improves large‐scale volume retention, elasticity, and support for vascularized tissue growth. The decellularized extracellular matrix (dECM)‐based material provides low injection force and minimizes swelling, ensuring sustained volume. Combining CMC with supercritical fluid‐
Seol‐Ha Jeong, Jae Jun Kang, Ki‐Myo Kim, Mi hyun lee, Misun Cha, Su Hee Kim, Ji‐Ung Park   +6 more
wiley   +1 more source

An Intervertebral Disc (IVD) Regeneration Model Using Human Nucleus Pulposus Cells (iHNPCs) and Annulus Fibrosus Cells (iHAFCs)

Advanced Healthcare Materials, EarlyView.
This study investigates hTert‐immortalized human nucleus pulposus (iHNPCs) and annulus fibrosus (iHAFCs) cells for intervertebral disc (IVD) regeneration and spinal fusion models. A 3D‐printed citrate‐based scaffold loaded with BMP9‐stimulated iHAFCs and BMP2‐stimulated iHNPCs effectively promotes bone and cartilage formation, mimicking the IVD ...
Yi Zhu, Qing Liu, Chao Yu, Hui Zhang, Jiamin Zhong, Yonghui Wang, Ou Mei, Ethan Gerhard, Wulin You, Guowei Shen, Changqi Luo, Xingye Wu, Jingjing Li, Yi Shu, Ya Wen, Usman Zeb, Hue H. Luu, Michael J. Lee, Lewis L. Shi, Yang Bi, Jian Yang, Jiaming Fan, Russell R. Reid, Tong‐Chuan He, Liangyuan Wen   +24 more
wiley   +1 more source

Advancing Chronic Wound Healing through Electrical Stimulation and Adipose‐Derived Stem Cells

Advanced Healthcare Materials, EarlyView.
Chronic cutaneous wounds represent significant challenges due to delayed healing and resistance to conventional treatments. This review explores the potential of combining adipose‐derived stem cells with electrical stimulation to enhance wound healing.
Qiuyue Peng, Yu Qian, Xinxin Xiao, Fengdi Gao, Guoqiang Ren, Cristian Pablo Pennisi   +5 more
wiley   +1 more source