Results 141 to 150 of about 755,441 (355)

The use of topical diclofenac in the pain management of osteoarthritis of the knee [PDF]

open access: yes, 2006
Osteoarthritis (OA) is a common complaint that affects millions of people worldwide. As there is no cure for OA, drug treatment is the main form of management.
Banning, M
core  

A Skin‐Adherent Magneto‐Inertial Wearable for Real‐Time Joint Motion Analysis

open access: yesAdvanced Sensor Research, EarlyView.
An imperceptible magneto‐inertial wearable couples a skin‐adherent PDMS‐NdFeB patch with a 9‐DoF IMU to track joint kinematics in real time and classify range‐of‐motion (Limited/Normal/Hypermobile) via a 1D‐CNN (95.3% accuracy). Wireless BLE streaming and a mobile app enable feedback.
Montserrat Ramirez‐De Angel   +2 more
wiley   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

open access: yesAdvanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian   +26 more
wiley   +1 more source

Surgical Relief of Pain in Paraplegic Patients [PDF]

open access: bronze, 1948
L. W. Freeman, Robert F. Heimburger
openalex   +1 more source

Do acetaminophen and an NSAID combined relieve osteoarthritis pain better than either alone? [PDF]

open access: yes, 2004
Combining nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen for short courses provides more relief of pain in osteoarthritis without an increase in side effects (strength of recommendation [SOR]=B).
Buescher, Jennifer J., Meadows, Susan E.
core  

M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy With Comorbid Traits

open access: yesAdvanced Science, EarlyView.
Genes associated with endometriosis risk are highly expressed in M2 macrophages, particularly ligands IL1A and IL1B. Endometrial‐type epithelium and stroma are likely recipients of these ligands. While IL1B treatment disturbs epithelial organization, blockage of the signaling results in a dose‐dependent decrease in spontanesous and evoked pain, reduces
Soledad Ochoa   +15 more
wiley   +1 more source

Steroid Receptor Coactivator‐1 Drives Tumor‐Associated Macrophage Reprogramming by Mediating MMP12 Transcription in Pancreatic Cancer Perineural Invasion

open access: yesAdvanced Science, EarlyView.
Steroid receptor coactivator‐1 (SRC‐1) reprograms tumor‐associated macrophages (TAMs) via signal transducer and activator of transcription 1(STAT1)‐mediated matrix metallopeptidase 12 (MMP12) transcription to drive perineural invasion (PNI) in pancreatic cancer.
Ke Cheng   +9 more
wiley   +1 more source

Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation

open access: yesAdvanced Science, EarlyView.
Ma et al. report the hippocampal and hepatic acetylcholine (ACh) levels are differently modulated by regular versus irregular exercise, which contributes to coordinate hippocampal astrocyte activity and hepatic FBXL6high neutrophil recruitment. This ACh‐modulated brain‐liver circuit links the effects of exercise on fear memory extinction and liver ...
Pengjiao Ma   +10 more
wiley   +1 more source

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