Results 181 to 190 of about 755,441 (355)

The Relief of Pain

open access: yesInternational Journal of Clinical Practice, 1984
openaire   +2 more sources

CGRP‐Loaded ROS‐Responsive Hydrogel Restores Neuro‐Angiogenic Signaling to Promote Bone Regeneration in Diabetes‐Associated Periodontitis

open access: yesAdvanced Science, EarlyView.
This study shows that diabetes damages sensory nerve fibers, especially CGRP‐positive ones, in the periodontium and disrupts autophagy in trigeminal ganglion neurons, affecting bone homeostasis by inhibiting type H vessel formation. To address this, CGRP@PVA/tsPBA hydrogels are developed to release CGRP in response to ROS, which binds to endothelial ...
Chaoning Zhan   +7 more
wiley   +1 more source

Houston, we have a problem of opioid crisis… and Rome?

open access: yesJournal of Anesthesia, Analgesia and Critical Care, 2023
Sebastiano Mercadante
doaj   +1 more source

A “Mesoporous Oxygen Chamber” Scaffold with Antibacterial and Early Immunomodulatory Effect for Promoting Bone Regeneration

open access: yesAdvanced Science, EarlyView.
In this study, an oxygen‐loaded and antimicrobial peptide (AP)‐functionalized scaffold (MBGAPO) is synthesized. With mesoporous structure of MBG applied as an “oxygen storage,” and AP‐provided antibacterial ability against E.coli and MRSA. MBGAPO exhibited osteogenic and multiplex‐immunomodulatory effects.
You Fu   +7 more
wiley   +1 more source

THE RELIEF OF PAIN

open access: yesBritish Journal of Anaesthesia, 1967
openaire   +2 more sources

KLK1 as an Epithelial‐Specific Brake Inhibits Colorectal Tumorigenesis by Suppressing B1R‐Mediated Fibroblast Phenotypic Transition

open access: yesAdvanced Science, EarlyView.
KLK1 downregulation disrupts the intestinal mucosal barrier and impairs kallikrein‐kinin signaling, thereby reducing Lys‐des‐Arg9‐BK production. This enhances B1R activation on ADAMDEC1⁺ fibroblasts, promoting inflammation and extracellular matrix (ECM) remodeling. The resulting iCAFs promote colorectal cancer progression, highlighting a novel KLK1‐B1R
Lisha Zhou   +14 more
wiley   +1 more source

Corticosteroid Injections for Pain Relief and Range of Motion in Adhesive Capsulitis. [PDF]

open access: yesCureus
Mannan M   +6 more
europepmc   +1 more source

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