Results 71 to 80 of about 755,441 (355)

Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function

Advanced Functional Materials, EarlyView.
Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh, Sanghee Lee, Soomin Cho, Kun Na   +3 more
wiley   +1 more source

Assessment of the relationship between central venous pressure waveform and the severity of tricuspid valve regurgitation using data science

Scientific Reports
Purpose The relationship between the height of the V wave in the central venous pressure (CVP) waveform and the severity of tricuspid regurgitation (TR) is well known. Their diagnostic ability is unconfirmed.
Shinichi Akabane, Masaaki Asamoto, Seiichi Azuma, Mikiya Otsuji, Kanji Uchida   +4 more
doaj   +1 more source

A randomised controlled trial to assess the effectiveness of a single session of nurse administered massage for short term relief of chronic non-malignant pain [PDF]

, 2008
Background: Massage is increasingly used to manage chronic pain but its benefit has not been clearly established. The aim of the study is to determine the effectiveness of a single session of nurse-administered massage for the short term relief of ...
A Williamson, CM Ceccio, D Rankin-Box, Dawn Carroll, DM Eisenberg, E Ernst, GF Wiesenger, HJ McQuay, June Martin, Kate Seers, Katrina Coulson, M Preyde, MJ Campbell, Nicola Crichton, R Melzack, Royal College of Nursing, S Mills, T Field, T Field, TM Marteau, W Sunshine, White House Commission   +21 more
core   +2 more sources

Micropatterned Biphasic Printed Electrodes for High‐Fidelity on‐Skin Bioelectronics

Advanced Functional Materials, EarlyView.
Micropatterned biphasic printed electrodes achieve unprecedented skin conformity and low impedance by combining liquid‐metal droplets with microstructured 3D lattices. This scalable approach enables high‐fidelity detection of ECG, EMG, and EEG signals, including alpha rhythms from the forehead, with long‐term comfort and stability.
Manuel Reis Carneiro, Telmo Lopes, André F. Silva, Carmel Majidi, Mahmoud Tavakoli   +4 more
wiley   +1 more source

The pain experiences of powered wheelchair users [PDF]

, 2011
Copyright © 2012 Informa UK, Ltd. This is the author's accepted manuscript. The final published article is available from the link below.Purpose: To explore the experience of pain and discomfort in users of electric-powered indoor/outdoor wheelchairs ...
Andrew O. Frank, Arthur S, Barnard M, Boninger ML, British Society of Rehabilitation Medicine, Claudius Neophytou, Cooper RA, Department of Health, Frank AO, Frank AO, Health &, Jock MT, Julia L. Frank, Krouskop TA, Lorraine H. De Souza, Ritchie J, Wolf E   +16 more
core   +1 more source

Transducer Materials Mediated Deep Brain Stimulation in Neurological Disorders

Advanced Functional Materials, EarlyView.
This review discusses advanced transducer materials for improving deep brain stimulation (DBS) in neurological disorders. These materials respond to light, ultrasound, or magnetic fields, enabling precise, less invasive neuromodulation. Their stimulus‐responsive properties enhance neural control and adaptive therapy, paving the way for next‐generation ...
Di Zhao, Zhengyang Cao, Guangjun Zhong, Limin Shi, Junxia Xie, Jianhua Hao   +5 more
wiley   +1 more source

Metal Nanoclusters for Cancer Imaging and Treatment

Advanced Functional Materials, EarlyView.
This review aims to provide a comprehensive summary and discussion of the core–shell design capabilities of metal nanoclusters (NCs) at the atomic level for cancer imaging and treatment. It offers essential insights into the design principles of metal NCs while also encouraging the exploration of other nanomaterials and their potential theranostic ...
Haiguang Zhu, Ziping Wang, Qiaofeng Yao, Ping Zhang, Jianping Xie, Xun Yuan   +5 more
wiley   +1 more source

Ethical and practical challenges in implementing informed consent in HIV/AIDS clinical trials in developing or resource-limited countries

SAHARA-J, 2009
Background/rationale: Ethical issues regarding HIV/AIDS human research in the developing world remain under continuous evaluation; a critical area of concern includes informed consent.
Kyriaki Mystakidou, Irene Panagiotou, Stelios Katsaragakis, Eleni Tsilika, Efi Parpa   +4 more
doaj   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

A better interpretation of data regarding the opioid switching to methadone

BMC Palliative Care, 2023
In a recent study methadone has been reported more effective witha 3-day switch (3DS) was more effective than the stop and go strategy (SAG). Many shorcomings, however, are of concerns. The poor selection fo patients with low level of pain intensity, the
Sebastiano Mercadante
doaj   +1 more source