Results 241 to 250 of about 3,446,688 (385)

The diversity and abundance of gut microbiota are associated with the pain sensation threshold in the Japanese population

open access: gold, 2022
Yuki Takeuchi   +16 more
openalex   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

open access: yesAdvanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian   +26 more
wiley   +1 more source

Pressure and cold pain threshold reference values in a pain-free older adult population. [PDF]

open access: yesBr J Pain
Waller R   +7 more
europepmc   +1 more source

Effects of Intraoperative Opioid Administration on Postoperative Pain and Pain Threshold: A Randomized Controlled Study. [PDF]

open access: yesJ Clin Med, 2022
Kawanaka R   +7 more
europepmc   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

open access: yesAdvanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang   +16 more
wiley   +1 more source

Pathophysiology of Nociception and Rare Genetic Disorders with Increased Pain Threshold or Pain Insensitivity. [PDF]

open access: yesPathophysiology, 2022
Cascella M   +6 more
europepmc   +1 more source

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