Results 251 to 260 of about 3,446,688 (385)

Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism

Advanced Science, EarlyView.
Glycosylation, specifically hypersialylation, is identified as a critical factor in human intervertebral disc (IVD) degeneration—a major cause of low back pain. This study demonstrates that inhibiting sialylation reduces inflammation and oxidative stress in IVD tissues, suggesting new therapeutic possibilities.
Kieran Joyce, Aert F. Scheper, Aung Myat Phyo, Roisin O’ Flaherty, Richard Drake, Aiden Devitt, Martina Marchetti‐Deschmann, Radka Saldova, Abhay Pandit   +8 more
wiley   +1 more source

Relationship Between Pressure Pain Threshold and Coping Strategies in Patients with Fibromyalgia [PDF]

, 1998
Jiyoung Song, Samuel Noh, Manfred Harth, Harold Merskey   +3 more
openalex   +1 more source

Grip strength, muscle soreness and pain threshold perception evolution in baseball pitchers in a simulated 75-pitch game: a repeated measures study. [PDF]

BMJ Open Sport Exerc Med
Tremblay M, Anderson Sirois S, Abboud J, Descarreaux M.   +3 more
europepmc   +1 more source

Modulation of pain threshold by virtual body ownership

European Journal of Pain, 2014
M. Martini, D. Pérez-Marcos, Maria V. Sanchez-Vives   +2 more
semanticscholar   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

PAIN THRESHOLD PARADOX IN SCHIZOPHRENIA: A NARRATIVE REVIEW BASED ON THE LASTEST NEUROSCIENCE

, 2023
Takahiko Nagamine
openalex   +1 more source

Predicting postoperative pain in children: an observational study using the pain threshold Index. [PDF]

Front Pediatr
Liang Z, Xie Y, Chen S, Liu J, Lv H, Muhoza BG, Xing F, Mao Y, Wei X, Xing N, Yang J, Wang Z, Yuan J.   +12 more
europepmc   +1 more source

Relationship between self-reported pain, pain threshold, pain catastrophization and quality of life in patients with TMD. [PDF]

J Clin Exp Dent, 2023
Januzzi MS, Neto CM, Moreno A, Dos Santos EG, de Caxias FP, da Silva EV, de Athayde FF, Volce AS, Rodrigues AS, Dela Líbera J, Turcio KH.   +10 more
europepmc   +1 more source

Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins

Advanced Science, EarlyView.
As newly emerged optogenetic tools, potassium channelrhodopsins (KCRs) can drift from inhibition to activation during illumination as K⁺ selectivity declines. It is shown that both the absolute K⁺/Na⁺ permeability ratio and its stability over time govern this drift, identify KCR1‐C29D as a reliably inhibitory variant, and outline design principles for ...
Xiao Duan, Chong Zhang, Stanislav Ott, Zhiyi Zhang, Christiane Ruse, Sven Dannhäuser, Robert Jacobi, Nadine Ehmann, Divya Sachidanandan, Georg Nagel, Manfred Heckmann, Robert J. Kittel, Alexander Gottschalk, Adam Claridge‐Chang, Shiqiang Gao   +14 more
wiley   +1 more source

Intranasal Administration of Acetaminophen-Loaded Poly(lactic-<i>co</i>-glycolic acid) Nanoparticles Increases Pain Threshold in Mice Rapidly Entering High Altitudes. [PDF]

Pharmaceutics
Huang Q, Han X, Li J, Li X, Chen X, Hou J, Yu S, Zhou S, Gong G, Shu H.   +9 more
europepmc   +1 more source