Results 311 to 320 of about 3,446,688 (385)

Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes

Advanced Science, EarlyView.
In TMJ‐OA, osteoclasts play a significant role in promoting the growth of sensory nerves at the osteochondral interface. In early OA, TRAP+ osteoclast‐derived SLIT3 induces sensory nerve growth into the condylar cartilage. This nerve growth facilitates the development of pain associated with OA.
Weiwei Zhu, Wenpin Qin, Jialu Gao, Yihan Guo, Xiaoxiao Han, Zhangyu Ma, Xiaokang Zhang, Jie He, Jing Liu, Bo Gao, Changjun Li, Lina Niu, Jianfei Yan, Kai Jiao   +13 more
wiley   +1 more source

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

Rescuing Mitochondrial Dysfunction in Macrophages Prevents Osteonecrosis of the Jaw in Anti‐Resorptive Therapy

Advanced Science, EarlyView.
Schematic model showing the suggested mechanism that ZA induces classical activation of macrophages by impairing mitochondrial biofunction and inhibiting mitochondrial clearance to contribute to the pathological process of BRONJ. RAPA‐loaded nanoparticles ZDPR has shown potential in alleviating BRONJ lesions as well as treating osteoporosis or ...
Hang Zhang, Xin Shen, Haiyang Liu, Xinxi Yuan, Mumin Cao, Xuepeng Lv, Ziji Ling, Songsong Guo, Rongyao Xu, Xiang Li, Hongbing Jiang   +10 more
wiley   +1 more source

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Pain Threshold

Time Being, 2011
M. Coons, J. Steglitz
semanticscholar   +3 more sources

Pressure Pain Threshold in Patients With Chronic Pain

American Journal of Physical Medicine & Rehabilitation, 2020
Supplemental digital content is available in the text. Introduction In chronic pain conditions, the pressure pain threshold has been used to investigate the presence of central sensitization.
Mohammadreza Amiri, M. Alavinia, Manveer Singh, D. Kumbhare   +3 more
semanticscholar   +1 more source

Does Manual Lymphatic Drainage Have Any Effect on Pain Threshold and Tolerance of Different Body Parts?

Lymphatic Research and Biology, 2019
Objective: The purpose of this study was to investigate the acute effects of manual lymphatic drainage (MLD) on pain threshold and pain tolerance of different body parts.
Ilke Keser, M. Esmer
semanticscholar   +1 more source

Pain-Free Versus Pain-Threshold Rehabilitation Following Acute Hamstring Strain Injury: A Randomized Controlled Trial.

Journal of Orthopaedic and Sports Physical Therapy, 2019
STUDY DESIGN Randomized controlled trial. BACKGROUND Conventional guidelines recommend hamstring strain injury (HSI) rehabilitation should only be performed and progressed in complete absence of pain, despite lack of comparison to alternative ...
J. Hickey, R. Timmins, N. Maniar, E. Rio, Peter F Hickey, Christian A. Pitcher, M. Williams, D. Opar   +7 more
semanticscholar   +1 more source

Experimental changes in pain threshold and severe pain threshold for electrically induced pain

Journal of Psychosomatic Research, 1990
Pain and severe pain thresholds were measured in groups of 15 (Experiment 1) and 20 (Experiment 2) normal volunteers. In Experiment 1, the subjects underwent a series of ten constant level, painful stimuli each of 10 sec duration at an arbitrarily chosen level between the thresholds. This level was recorded.
J L, Collier, B M, Mehta, F G, Spear
openaire   +2 more sources

Behavioral Measures of Pain Thresholds

Current Protocols in Mouse Biology, 2011
AbstractPain afflicts a fifth of the population, and animal models have proven useful in target validation and analgesic drug development. Thresholds to pain are tested by applying a sensory stimulus, such as heat or pressure, and observing the resulting withdrawal behavior.
Michael S, Minett, Kathryn, Quick, John N, Wood   +2 more
openaire   +2 more sources

Sensory Deprivation and Pain Thresholds

Science, 1961
Four days of sensory deprivation produced a significant lowering of thresholds for electrically induced pain.
J, VERNON, T E, McGILL
openaire   +2 more sources