Results 51 to 60 of about 25,476 (312)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Photo art creativity in the education: Light drawing

SHS Web of Conferences, 2016
Since the early ages, people live together with art, and create various branches of art. Painting, as one of the most important branches of art, occurs on the walls of the caves of prehistoric ages. By the nineteenth century, photography shows itself and
Acar Haci Mehmet, Kavuran Tamer
doaj   +1 more source

The young Van Dyck’s fingerprint: a technical approach to assess the authenticity of a disputed painting

Heritage Science, 2017
The painting Saint Jerome, part of the collection of the Maagdenhuis Museum (Antwerp, Belgium), is attributed to the young Anthony van Dyck (1613–1621) with reservations.
Astrid Harth, Geert Van der Snickt, Olivier Schalm, Koen Janssens, Griet Blanckaert   +4 more
doaj   +1 more source

Multiband Photogrammetry and Hybrid Image Analysis for the Investigation of a Wall Painting by Paolo de San Leocadio and Francesco Pagano in the Cathedral of Valencia

Sensors, 2023
A workflow for the photogrammetric combination of non-invasive multispectral imaging techniques ranging from ultraviolet (UV) and visible (VIS) to near infrared (NIR) for the investigation of wall paintings is presented.
Max Rahrig, Miguel Ángel Herrero Cortell, José Luis Lerma   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Comparative Study of Religious Narration of Gothic and Coffee House Paintings [PDF]

نگره, 2018
Religious art is rooted in theology and teachings of the same religion, such as the religious Coffee House painting and also the Gothic painting. School of Coffee House painting was formed and became widespread in the late 13th and early 14th century AD.
azam hakim, Abolghasem Dadvar
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

From Flanders to Portugal: A Portuguese Painter in Pursuit of Prestigious Flemish Painting—Materials and Techniques Compared Through an Analytical Approach

Heritage
This study offers fresh insights into the technical and stylistic exchanges between Flemish and Portuguese panel painting during the late 15th and early 16th centuries.
Vanessa Antunes, António Candeias, José Mirão, Sara Valadas, Ana Cardoso, Maria José Francisco, Alexandra Lauw, Marta Manso, Maria Luísa Carvalho   +8 more
doaj   +1 more source

The Girl in the Spotlight: Vermeer at work, his materials and techniques in Girl with a Pearl Earring

Heritage Science, 2020
The 2018 technical examination project The Girl in the Spotlight aimed to characterise the materials and techniques that Johannes Vermeer used to paint Girl with a Pearl Earring (c. 1665, Mauritshuis).
Abbie Vandivere, Jørgen Wadum, Emilien Leonhardt   +2 more
doaj   +1 more source