Results 221 to 230 of about 8,742,018 (356)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Lepton pair production in muon-nucleus scattering

open access: yesPhysics Letters B
The MUonE experiment aims at providing a novel determination of the leading hadronic contribution to the muon anomalous magnetic moment through the study of elastic muon-electron scattering.
G. Abbiendi   +4 more
doaj  

Higgs pair production in vector-boson fusion at the LHC and beyond. [PDF]

open access: yesEur Phys J C Part Fields, 2017
Bishara F, Contino R, Rojo J.
europepmc   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald   +18 more
wiley   +1 more source

Boosting Higgs pair production in the [Formula: see text] final state with multivariate techniques. [PDF]

open access: yesEur Phys J C Part Fields, 2016
Behr JK   +5 more
europepmc   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

Searches for pair production of third-generation squarks in [Formula: see text][Formula: see text] pp collisions. [PDF]

open access: yesEur Phys J C Part Fields, 2017
Sirunyan AM   +2241 more
europepmc   +1 more source

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