Results 111 to 120 of about 513,160 (336)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Suggestion and Upgrading Extreme Programming Methodology in Web-Based Project Development
Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017 In this research, we will discuss how to improve the work by dealing with the factors that participates in enhancing small IT organization to produce the software using the suitable development process supported by experimental theories to achieve the
A.Y. Gheni
doaj
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Concepts and their Use for Modelling Objects and References in Programming Languages
, 2007 In the paper a new programming construct, called concept, is introduced. Concept is pair of two classes: a reference class and an object class. Instances of the reference classes are passed-by-value and are intended to represent objects. Instances of the
Savinov, Alexandr
core +1 more source
Psychological Aspects of Pair Programming
, 2023 With the recent advent of artificially intelligent pairing partners in software engineering, it is interesting to renew the study of the psychology of pairing. Pair programming provides an attractive way of teaching software engineering to university students.
openaire +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Existence of Equilibrium in Discrete Market Games [PDF]
In this paper we show that a feasible price allocation pair is a market equilibrium of a discrete market game if and only if it solves a linear programming problem.
Somdeb Lahiri
core
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source