Results 151 to 160 of about 7,975,657 (382)

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

SynergyAI: A Human–AI Pair Programming Tool Based on Dataflow

Information
This paper proposes SynergyAI, an AI–human pair programming tool that represents predictive models as dataflows composed of AI, input, and output nodes.
Le Jiang, Shingo Yamaguchi, Mohd Anuaruddin Bin Ahmadon   +2 more
doaj   +1 more source

An Approach to Programming Based on Concepts [PDF]

Institute of Mathematics and Computer Science, Academy of Sciences of Moldova, Technical Report RT0005, 2007, 2007
In this paper we describe a new approach to programming which generalizes object-oriented programming. It is based on using a new programming construct, called concept, which generalizes classes. Concept is defined as a pair of two classes: one reference class and one object class.
arxiv  

A computer program to evaluate paired-comparison transitivity [PDF]

, 1980
Edward Burns
openalex   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Human-Centric Program Synthesis [PDF]

arXiv, 2019
Program synthesis techniques offer significant new capabilities in searching for programs that satisfy high-level specifications. While synthesis has been thoroughly explored for input/output pair specifications (programming-by-example), this paper asks: what does program synthesis look like beyond examples? What actual issues in day-to-day development
arxiv  

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Measuring mutual engagement in the context of middle-school pair programming: Development and validation of a self-reported questionnaire

Computers in Human Behavior Reports
With the increasing importance of equipping young learners with computational thinking skills through learning to code, pair programming has emerged as a prevalent collaborative learning strategy in this context. Successful pair programming interventions
Fan Xu, Ana-Paula Correia
doaj  

Programmable chirp compensation for 6-fs pulse generation with a prism-pair-formed pulse shaper [PDF]

, 2000
Lina Xu, Naofumi Nakagawa, Ryuji Morita, Hidemi Shigekawa, Mikio Yamashita   +4 more
openalex   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source