Results 91 to 100 of about 697,689 (262)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

PRECEPTORSHIP METHOD TO THE ACHIEVEMENT OF NEW NURSE COMPETENCIES AT RUMAH SAKIT ISLAM SURABAYA JEMURSARI

Jurnal Ilmiah Kesehatan, 2019
Background: Competency issues and the lack of implementation of an orientation program with the preceptorship method are problems and require solutions / solutions.
yuliartiningsih yuliartiningsih, yanis kartini, nursalam nursalam   +2 more
doaj   +1 more source

IMPROVING STUDENTS LISTENING COMPREHENSION AT SMKN 1 TANAH GROGOT EAST KALIMANTAN USING DICTOGLOSS STRATEGY [PDF]

The research aims to determine whether the dictogloss strategy improves listening comprehension at SMKN 1 Tanah Grogot or not. The design of this research is quasi-experimental. The population of this research was the students of SMK N 1 Tanah Grogot and
Hasanna, Salsabilla Kirananda
core  

Pengungkapan Corporate Social Responsibility (CSR) Sebelum Dan Sesudah Diberlakukannya UU No. 40 Tahun 2007 Tentang Perseroan Terbatas [PDF]

, 2016
Penelitian ini bertujuan untuk mengetahui apakah terdapat perbedaan pengungkapan Corporate Social Responsibility sebelum dan sesudah berlakunya UU Nomor 40 Tahun 2007 tentang Perseroan Terbatas.
Apriliawati, A. (AFitria), Hariyanto, W. (Wiwit)   +1 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Perbedaan Kadar Gula Darah Setelah Terapi Bekam Basah Dan Pijat Refleksi Pada Penderita Diabetes Mellitus Di Karangmalang Sragen [PDF]

, 2015
Diabetes mellitus is one of the non-communicable diseases that occur on a person because an increase blood glucose levels as a result of progressive insulin secretion because decreased insulin resistance.
, Arief Wahyudi Jadmiko, S. Kep., Ns., M. Kep,, , Winarsih Nur Ambarwati, S. Kep., Ns., ETN., M. Kep, WULANDARI, RATRI   +2 more
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Peningkatan Hasil Belajar Mata Kuliah Perpajakan Pokok Bahasan Pph PSL 21 dengan Pendekatan Problem Posing Mahasiswa Pendidikan Ekonomi Universitas Riau [PDF]

, 2013
Tujuan penelitian ini adalah untuk mengetahui dan menganalisis apakah hasilbelajar mahsiswa meningkat dengan menggunakan pendekatan problem posingdalam pengajaran mata kuliah perpajakan pokok bahasan pajak penghasilan pasal21. Penelitian ini dilaksanakan
Gusnardi, G. (Gusnardi)
core  

The Differences and Similarities Between Two-Sample T-Test and Paired T-Test

, 2017
In clinical research, comparisons of the results from experimental and control groups are often encountered. The two-sample t-test (also called independent samples t-test) and the paired t-test are probably the most widely used tests in statistics for the comparison of mean values between two samples. However, confusion exists with regard to the use of
FRALICK, Drew, ZHENG, Julia Z., Wang, Bokai, TU, Xin M., FENG, Changyong   +4 more
openaire   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source