Results 141 to 150 of about 832,547 (326)
Centromeric SMC1 promotes centromere clustering and stabilizes meiotic homolog pairing.
PLoS Genetics, 2019 During meiosis, each chromosome must selectively pair and synapse with its own unique homolog to enable crossover formation and subsequent segregation.
Talia Hatkevich +5 more
doaj +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
On a pair of ciliated grooves in the brain of the ammocœte apparently serving to promote the circulation of the fluid in the brain-cavity [PDF]
, 1902 Arthur Dendy
openalex +1 more source
Journal of Pure and Applied Algebra, 1992 All rings are commutative with identity. An \(R\)-module \(M\) is said to satisfy accr if, for every submodule \(N\) of \(M\) and every finitely generated ideal \(I\) of \(R\), the ascending chain \[ {(N:I)\subseteq(N:I^ 2)\subseteq(N:I^ 3)\subseteq\dots} \] terminates. Rings and modules satisfying this condition have been studied by \textit{C.-P. Lu} [
openaire +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Infantile hypertrophic pyloric stenosis: data on 81 pairs of twins [PDF]
, 1955 Brian MacMahon, Thomas McKeown
openalex +1 more source
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Relative amplitude in the mixed-spin pn superfluid phase
Physics Letters BSimilar to short-range correlated electron pairs under the constraint of long-range Coulomb interaction, which describe condensed atomic states, isoscalar (T=0) and isovector (T=1) pn correlations, including short-range pairing and long-range non-pairing
F.F. Zeng +3 more
doaj +1 more source