Results 41 to 50 of about 241,816 (288)

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source

La necesidad de cumplimiento de la reparación integral en casos de violencia intrafamiliar desde el Código Orgánico Integral Penal en Ecuador

Chornancap
La violencia intrafamiliar, vinculada históricamente a factores sociales como el patriarcado, ha sido reconocida en Ecuador como una problemática relevante dentro del ámbito constitucional y penal, especialmente en el artículo 159° del Código Orgánico ...
Ivonne Magdalena Enríquez Palate
doaj   +1 more source

Temporal development of compensation strategies for perturbed palate shape in German /S/-production [PDF]

, 2006
The palate shape of four speakers was changed by a prosthesis which either lowered the palate or retracted the alveoles. Subjects wore the prosthesis for two weeks and were recorded several times via EMA.
Brunner, Jana, Fuchs, Susanne, Hoole, Phil, Perrier, Pascal   +3 more
core  

Staging an Experience of Cultural Heritage Preservation: Consumers' Willingness to Pay for Heirloom Rice in the Philippines

Agribusiness, EarlyView.
ABSTRACT The Cordillera Administrative Region in the Philippines is home to terraced rice embedded in centuries of cultural heritage. However, weak market incentives threaten sustained production, jeopardizing indigenous communities' cultural heritage and the in situ biodiversity of rice genetic resources.
Kofi Britwum, Matty Demont
wiley   +1 more source

The Architects Collaborative in Cyprus: Archaeo-Tourism and Landscape Configurations 

Architectural Histories
The Amathus Beach Hotel was the first project for The Architects Collaborative in Cyprus, which it undertook in collaboration with local Greek Cypriot architectural firm Colakides & Associates. Completed in 1973, the project was embarked on at a time
Panayiota Pyla, Savia Palate
doaj   +2 more sources

Oro-facial clefts at a tertiary level hospital of eastern Nepal: A retrospective insight

Journal of Cleft Lip Palate and Craniofacial Anomalies, 2022
Introduction: There are only a few centers providing care to orofacial cleft patients across Nepal. However, no adequate data have been reported regarding the epidemiology, pattern, and association of cleft in children from eastern Nepal.
Mehul R Jaisani, Ashok Dongol, Pradeep Acharya, Anjani Kumar Yadav, Alok Sagtani, Leeza Pradhan, Pallavi Vyas Jaisani, Sean Laverick   +7 more
doaj   +1 more source

The acrocallosal syndrome: A case report and literature survey [PDF]

, 2009
Acrocallosal syndrome (ACS) is a rare, genetically transmitted disorder characterized by facial deformities. These include a large forehead, large anterior fontanelle, broad nasal bridge with increased intercanthal distance, partial or complete agenesis ...
Davies, Lindsey, Gonzales, Cesar, Hodgson, Brian   +2 more
core   +1 more source

Ear- and hearing-related impact on quality of life in children with cleft palate : development and pretest of a health-related quality of life (HRQOL) instrument

, 2019
Objectives: To investigate to what extent middle ear problems and associated hearing loss affect quality of life (QoL) of children born with a cleft palate. Methods: Fifty-five children aged between 6 and 18 years, born with non-syndromic cleft palate +/
De Leenheer, Els, De Paepe, Justine, Dochy, Frederick, Van Hoecke, Helen, Willems, Sara   +4 more
core   +2 more sources

A rare case of melanosis of the hard palate mucosa in a patient with chronic myeloid leukemia [PDF]

, 2015
Imatinib Mesylate, also known as Gleevec or ST1-571, is a tyrosine-kinase inhibitor used as the gold standard medication for the chronic myeloid leukemia (CML); Imatinib has indeed deeply revolutionized the CML therapy allowing most patients to have a ...
Bosco, Daniela, Fantozzi, Paolo Junior, Palaia, Gaspare, Romeo, Umberto, Tenore, Gianluca   +4 more
core   +3 more sources

From Multiple Congenital Anomalies to Pituitary Gland Malformation: Wide Spectrum of Clinical Features in a Family With FOXA2 Variant

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT FOXA2 (hepatocyte nuclear factor‐3β, HNF‐3β) encodes a transcriptional activator involved in early embryogenesis, particularly in the patterning and differentiation of midline structures such as the neural tube, foregut, and pituitary gland. Its role in human pathogenesis was first suspected when patients with deletion of chromosome 20p11.2 ...
Christopher Connolly, Hemant A. Parmar, Lauren Hipp, Tomoyasu Higashimoto   +3 more
wiley   +1 more source