Results 141 to 150 of about 711,163 (355)

The American species of the annulatipes group of the subgenus Lepidohelea, genus Forcipomyia (Diptera: Ceratopogonidae) [PDF]

open access: yes, 2010
The annulatipes group of the genus Forcipomyia Meigen, subgenus Lepidohelea Kieffer, is represented in the Western Hemisphere by 12 species. Keys are presented for their identification, and to distinguish them from other groups of the subgenus ...
Spinelli, Gustavo R., Wirth, Willis W.
core  

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

open access: yesAdvanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance   +17 more
wiley   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

open access: yesAdvanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang   +16 more
wiley   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

open access: yesAdvanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang   +16 more
wiley   +1 more source

West Indian species of Beameromyia Martin (Diptera: Asilidae) [PDF]

open access: yes, 2011
The West Indian species of Beameromyia Martin are reviewed. Four new species are described, and Beameromyia insulara Martin and B. cubensis (Bigot) are redescribed.
Scarbrough, Aubrey G.
core  

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

open access: yesAdvanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao   +36 more
wiley   +1 more source

Etude de l'impact sur pale d'hélicoptère [PDF]

open access: yes, 2005
Le présent article propose une étude de l’endommagement de structures similaires à des tronçons de pales d’hélicoptère soumises à un impact. Il s’agit de structures composites complexes, fabriquées au laboratoire, et impactées par un projectile de 125 g
Barrau, Jean-Jacques   +4 more
core  

Bioabsorbable Endovascular Adhesive Tape (BEAT) for Improving Vascular Regeneration

open access: yesAdvanced Science, EarlyView.
A bioabsorbable endovascular adhesive tape (BEAT) platform based on a hierarchical polyelectrolyte complex is developed to enhance drug delivery in the DCB system. The coating enables rapid transfer to the vessel, provides short‐term mechanical support, and promotes both immediate transfer and long‐term retention of drugs at the lesion site.
Jiarong Wang   +13 more
wiley   +1 more source

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