Results 101 to 110 of about 22,766 (265)
iMeta, EarlyView.This study proposes an innovative therapeutic approach by combining RRM2 gene knockout with a nanocarrier system, significantly enhancing the efficacy of radiofrequency ablation for hepatocellular carcinoma. The study developed a tumor microenvironment‐responsive nanosystem that achieves synergistic effects through SPIO‐mediated and RRM2 knockout ...
Weiliang Hou +19 more
wiley +1 more source
New insights into applications of base editor in hereditary disorders
Interdisciplinary Medicine, EarlyView.Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai +8 more
wiley +1 more source
The effects of trinucleotide repeats found in human inherited disorders on palindrome inviability in Escherichia coli suggest hairpin folding preferences in vivo. [PDF]
, 1995 John M. Darlow, David R. F. Leach
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Interdisciplinary Medicine, EarlyView.Abstract Isothermal amplification (IA) techniques have emerged as promising alternatives to polymerase chain reaction (PCR), enabling rapid and efficient nucleic acid amplification at constant temperatures. Meanwhile, clustered regularly interspaced short palindromic repeat (CRISPR)/Cas‐based technology has revolutionized molecular diagnostics by ...
Miao Liu +7 more
wiley +1 more source
Tissue-Restricted Expression of the Cardiac α-Myosin Heavy Chain Gene Is Controlled by a Downstream Repressor Element Containing a Palindrome of Two Ets-Binding Sites [PDF]
, 1998 Madhu Gupta +3 more
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HPV Integration: Moving From Carcinogenesis Mechanisms to Clinical Applications
Med Research, EarlyView.ABSTRACT Human papillomavirus (HPV) is the leading cause of virus‐associated carcinomas, most notably cervical cancer and head and neck cancers. A central mechanism driving HPV‐induced carcinogenesis is the integration of viral DNA into the host genome.
Shaoyang Lai +3 more
wiley +1 more source
BfiI, a restriction endonuclease from Bacillus firmus S8120, which recognizes the novel non-palindromic sequence 5'-ACTGGG(N)5/4-3' [PDF]
, 1998 Jolanta Vitkute +3 more
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Pest Management Science, Volume 81, Issue 4, Page 1988-1999, April 2025.Schematic diagram of the single and dual RPA‐CRISPR/Cas12a/13a diagnostic assays for the detection of Pantoea stewartii subsp. stewartii and Maize dwarf mosaic virus. The validated assays provide a useful and sensitive molecular tool for detecting two quarantine pathogens of maize within a minimal resource framework suitable for fast‐tracking the ...
Qian Tian +6 more
wiley +1 more source
, 2014 A palindrome in base $g$ is an integer $N$ that remains the same when its digit expansion in base $g$ is reversed. Let $g$ and $h$ be given distinct integers $>1$. In this paper we discuss how many integers are palindromes in base $g$ and simultaneously palindromes in base $h$.
Bérczes, Attila, Ziegler, V.
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Interleukin‐1 receptor type II and inflammatory bowel disease: A Mendelian randomization study
Rheumatology &Autoimmunity, EarlyView.This Mendelian Randomization study investigated the association between interleukin‐1 receptor type II (IL‐1RII) and inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC) by utilizing the genome‐wide association studies summary statistics.
Qifan Feng +7 more
wiley +1 more source