Results 31 to 40 of about 11,659 (270)
FrCas9 is a CRISPR/Cas9 system with high editing efficiency and fidelity
Nature Communications, 2022 Gene editing tools have tremendous potential for biomedical and basic research. Here the authors report a Cas9 from Faecalibaculum rodentium (FrCas9) that achieves efficient and specific gene editing in human cells with a NNTA palindrome PAMs for ...
Zifeng Cui +14 more
doaj +1 more source
Growth Inhibitory Efficacy of Tabebuia Avellanedae in a Model for Triple Negative Breast Cancer
Archives of Breast Cancer, 2021 Background: Tabebuia avellanedae (TA) is a tree that is indigenous to the Amazon rainforest. The experiments in the present study were designed to examine the inhibitory effects of TA, and to identify mechanistic targets for its efficacy in the estrogen ...
Nitin T Telang +2 more
doaj +1 more source
Growth Inhibitory Efficacy of Chinese Herbs in a Cellular Model for Triple-Negative Breast Cancer
Pharmaceuticals, 2021 Triple-negative breast cancer (TNBC) is characterized by the absence of estrogen receptor-α progesterone receptor and human epidermal growth factor receptor-2.
Nitin T. Telang +2 more
doaj +1 more source
Discrete m-functions with Doubly Palindromic Continued Fraction Coefficients [PDF]
arXiv, 2022 We demonstrate that discrete m-functions with eventually periodic continued fraction coefficients have an algebraic relationship to their second solution if and only if the periodic part of the sequence of continued fraction coefficients is doubly palindromic.
arxiv
Relationship between NAFLD and coronary artery disease: A Mendelian randomization study
Hepatology, EarlyView., 2022 Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren +4 more
wiley +1 more source
Analyses of the Sequence and Structural Properties Corresponding to Pentapeptide and Large Palindromes in Proteins. [PDF]
PLoS ONE, 2015 The analyses of 3967 representative proteins selected from the Protein Data Bank revealed the presence of 2803 pentapeptide and large palindrome sequences with known secondary structure conformation. These represent 2014 unique palindrome sequences.
Settu Sridhar +2 more
doaj +1 more source
Double-Ended Palindromic Trees: A Linear-Time Data Structure and Its Applications [PDF]
arXiv, 2022 The palindromic tree (a.k.a. eertree) is a linear-size data structure that provides access to all palindromic substrings of a string. In this paper, we propose a generalized version of eertree, called double-ended eertree, which supports linear-time online double-ended queue operations on the stored string.
arxiv
Hepatology, EarlyView., 2022 A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan +19 more
wiley +1 more source
Characterizing the evolution and phenotypic impact of ampliconic Y chromosome regions
Nature Communications, 2023 A major part of the human Y chromosome consists of palindromes with multiple copies of genes primarily expressed in testis, many of which have been claimed to affect male fertility.
Elise A. Lucotte +8 more
doaj +1 more source
Enfermería Nefrológica, 2022 Introducción: La disfunción y las infecciones son las causas más frecuentes de retirada de los catéteres venosos centrales tunelizados para hemodiálisis.
Juan Manuel Manzano Angua +4 more
doaj +1 more source