Results 141 to 150 of about 2,912,653 (308)

Development and Application of Organic Sonosensitizers in Cancer Therapy

Aggregate, EarlyView.
This review provides a comprehensive overview of organic sonosensitizers employed in cancer treatment, describing their underlying mechanisms and structure‐activity relationship in terms of sonodynamic therapy. The significance of nanotechnology and combination therapy with other oncological modalities (photothermal therapy, photodynamic therapy, etc.)
Yuhan Ding, Yuchen Yang, Omer Aras, Feifei An, Mengjiao Zhou, Yichao Chai   +5 more
wiley   +1 more source

Progress in COVID research and developments during pandemic

VIEW, Volume 3, Issue 6, December 2022., 2022
The pandemic respiratory disease COVID‐19 has spread over the globe within a small span of time. Generally, there are two important points are being highlighted and considered towards the successful diagnosis and treatment process. The first point includes the reduction of the rate of infections and the next one is the decrease of the death rate.
Sudheesh K. Shukla, Santanu Patra, Trupti R. Das, Dharmesh Kumar, Anshuman Mishra, Ashutosh Tiwari   +5 more
wiley   +1 more source

Enhanced breast cancer cell targeting: RGD integrin ligand potentiates RWQWRWQWR’s cytotoxicity and inhibits migration [PDF]

Exploration of Drug Science
Aim: Evaluate the selective cytotoxic effect of the palindromic sequence RWQWRWQWR and its analogues obtained by replacement of L-amino acids by D-amino acids or the functionalization by adding the RGD (integrin ligand motif) to the peptide.
Andrea Barragán-Cárdenas, Daniel Castellar-Almonacid, Yerly Vargas-Casanova, Claudia Parra-Giraldo, Adriana Umaña-Pérez, Joel López-Meza, Zuly Rivera-Monroy, Javier García-Castañeda   +7 more
doaj   +1 more source

The Euler characteristic of the Whitehead automorphism group of a free product [PDF]

, 2006
A combinatorial summation identity over the lattice of labelled hypertrees is established that allows one to gain concrete information on the Euler characteristics of various automorphism groups of free products of groups.Comment: 19 pages, 3 figures, to
Jensen, Craig, McCammond, Jon, Meier, John   +2 more
core   +3 more sources

Application of humanized mice in the safety experiments of antibody drugs

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun, Mengyun Gu, Zixuan Yang, Lei Shi, Liyuan Zhao, Minhui Zheng, Yan Wang, Wei Zhang, Kexin Han, Naping Tang   +9 more
wiley   +1 more source

Palindrome complexity [PDF]

Theor. Comput. Science 292 (2003) 9 - 31, 2001
We study the palindrome complexity of infinite sequences on finite alphabets, i.e., the number of palindromic factors (blocks) of given length occurring in a given sequence. We survey the known results and obtain new results for some sequences, in particular for Rote sequences and for fixed points of primitive morphisms of constant length belonging to ...
arxiv  

Spider Eye Development Editing and Silk Fiber Engineering Using CRISPR‐Cas

Angewandte Chemie International Edition, EarlyView.
Spiders exhibit unique traits with significant implications for a diversity of fields, and gene editing provides new opportunities for advancing research in these areas. In this study, we developed a CRISPR‐Cas9 protocol for spiders, enabling gene knock‐outs/knock‐ins to study gene function and introduce new phenotypic traits. Abstract CRISPR‐Cas9 gene
Edgardo Santiago‐Rivera, Thomas Scheibel   +1 more
wiley   +1 more source

CRISPR applications for Duchenne muscular dystrophy: From animal models to potential therapies

WIREs Mechanisms of Disease, Volume 15, Issue 1, January/February 2023., 2023
CRISPR‐Cas9 gene‐editing technology enables the rapid generation of animal models for Duchenne muscular dystrophy research and has potential to be developed as CRISPR therapy for the long lasting genetic correction of causal mutations. Abstract CRISPR gene‐editing technology creates precise and permanent modifications to DNA.
Yu C. J. Chey, Jayshen Arudkumar, Annemieke Aartsma‐Rus, Fatwa Adikusuma, Paul Q. Thomas   +4 more
wiley   +1 more source

Clinical variants in Caenorhabditis elegans expressing human STXBP1 reveal a novel class of pathogenic variants and classify variants of uncertain significance

Genetics in Medicine Open, 2023
Purpose: Modeling disease variants in animals is useful for drug discovery, understanding disease pathology, and classifying variants of uncertain significance (VUS) as pathogenic or benign.
Christopher E. Hopkins, Kathryn McCormick, Trisha Brock, Matthew Wood, Sarah Ruggiero, Kolt Mcbride, Christine Kim, Jennifer A. Lawson, Ingo Helbig, Matthew N. Bainbridge   +9 more
doaj  

Enumerating Segmented Patterns in Compositions and Encoding by Restricted Permutations

, 2005
A composition of a nonnegative integer (n) is a sequence of positive integers whose sum is (n). A composition is palindromic if it is unchanged when its terms are read in reverse order.
Kitaev, Sergey, McAllister, Tyrrell B., Petersen, T. Kyle   +2 more
core   +3 more sources