Results 61 to 70 of about 1,342 (166)

Integrated Methylome–Transcriptome Analysis Reveals Epigenomic Remodeling and Rho GTPase–Linked Immune–Epithelial Crosstalk in Atopic Dermatitis

Allergy, EarlyView.
Integrated methylome–transcriptome–microbiome analysis of AD skin identified thousands of DMRs. Rho GTPase signaling and actin–junctional programs emerged as central hubs integrating immune, epithelial, and microbial interactions in the pathogenesis of atopic dermatitis.
Tiina Skoog, Ying Yang, Peter Olah, Shintaro Katayama, Piia Karisola, Catherine Smith, Stephan Weidinger, Jonathan Barker, Antti Lauerma, Björn Andersson, Bernhard Homey, Nanna Fyhrquist, Juha Kere, Harri Alenius, MAARS Consortium, Francesca Levi‐Schaffer, Dario Greco, Stefanie Prast‐Nielsen, Vassili Soumelis, Sophia Tsoka, Jens M. Schröder, Frank O. Nestle, Philippe Hupé   +22 more
wiley   +1 more source

Five Decades of Innovation—Tailored Breast Cancer Treatment: 1976–2026

World Journal of Surgery, EarlyView.
Ipshita Prakash, Pooja Ramakant, Sandra Krishnan, Sharon W. W. Chan, Tadahiko Shien, Kavitha Daester, Michael Douek, Mee Hoong See, Jacqueline Jeruss, Cheng‐Har Yip, Ines Buccimazza   +10 more
wiley   +1 more source

Information and affective valence influence judgments of complexity, liking and understanding

British Journal of Psychology, EarlyView.
Abstract Visual complexity is a key factor in perceptual and evaluative judgments. People's representation of visual complexity is constructed from quantitative and structural image features, but it is also influenced by familiarity and expertise. We examined how people represent visual complexity and its impact on perception and evaluation, focusing ...
Xiaolei Sun, Jiajia Che, Marcos Nadal, Helmut Leder   +3 more
wiley   +1 more source

BloomTree: Dynamic Coloring Techniques for Exploring Deep and Wide Tree Structures

Computer Graphics Forum, EarlyView.
Abstract This study introduces BloomTree, an interactive Sunburst system for visualizing massive hierarchical datasets, such as the Tree of Life. Traditional static color schemes fail to maintain perceptual distinguishability when applied to millions of nodes, and managing the full tree in memory is computationally costly.
A. Tanaka, K. Wakita
wiley   +1 more source

Environmental justice in education for climate action: Case studies from Perú and Uganda

Children &Society, EarlyView.
Abstract This paper draws on participatory research with secondary school learners in Perú and Uganda that shows how environmental and social (in) justices are interwoven and embedded in young people's experiences of the natural world. These experiences contrast with learners' accounts of environmental education in secondary schooling, in which the ...
Rachel Wilder, Expedito Nuwategeka, Carlos Monge, Alithu Bazan Talavera   +3 more
wiley   +1 more source

Risks of concealing environmental degradation

Conservation Biology, EarlyView.
Abstract Current practice seeks to conceal the visual impact of land‐use change (i.e., development). Six percent of development impact assessments in Australia and 14% of the World Bank's assessments recommend visual impact mitigation. This mitigation results in, for example, vegetated buffer strips alongside cleared agricultural areas and earthen ...
Matt W. Hayward, Kaya Klop‐Toker, Salim Momtaz, Eliza Payne, Louisa Rebec, Robert J. Scanlon, Craig M. Shuttleworth, Nick Valentine, Andrea S. Griffin   +8 more
wiley   +1 more source

Factors affecting early plant survival in restoration of Mediterranean‐type climate shrublands

Conservation Science and Practice, EarlyView.
We undertook post‐fire restoration in southern California's shrubland with some portion of plants receiving supplemental irrigation. After 2.5 years survival was higher in California sage scrub (CSS) versus chaparral species and only slightly higher in irrigated individuals.
Emma C. Underwood, R. Brandon Pratt, Anna L. Jacobsen, Nicole A. Molinari, Josie Lesage, Neda Brehm, Denise Knapp, Shane Dewees, Antonio Mateiro, Ernesto Chavez   +9 more
wiley   +1 more source

A noncanonical role for Jagged1 in endothelial mechanotransduction

The FEBS Journal, EarlyView.
This study reveals a noncanonical role for Jagged1 in endothelial mechanotransduction. Shear stress modulates Jagged1 expression and subcellular localization. Loss of Jagged1 attenuates mechanotransduction and reduces Src, VEGFR2, and ERK signaling. Direct mechanical stimulation of Jagged1 induces activation of these signaling pathways.
Freddy Suarez Rodriguez, Noora Virtanen, Elmeri Kiviluoto, Rob C. H. Driessen, Feihu Zhao, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren   +7 more
wiley   +1 more source

A patient‐centered conceptual model and measurement framework for migraine experience developed by the Migraine Clinical Outcome Assessment System

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To develop a comprehensive, evidence‐based, patient‐centered conceptual model of migraine and to derive a measurement framework for the development or selection of clinical outcome assessments used in clinical trials of treatments for migraine.
Rikki Mangrum, Alexandra L. Bryant, Carrie R. Houts, James S. McGinley, Dawn C. Buse, Richard B. Lipton, R. J. Wirth   +6 more
wiley   +1 more source

Standing on a common ground: a comparison of static stability approaches for pallet loading

International Transactions in Operational Research, EarlyView.
Abstract At the practical level, the static stability constraint is one of the most important constraints in practical pallet loading problems, such as air cargo palletizing. Approaches to modeling static stability, which range from base support and mechanical equilibrium calculations to physical simulation, differ in workflow, focus, and assumptions ...
Philipp G. Mazur, Frederick C. Gamer, António G. Ramos, Detlef Schoder   +3 more
wiley   +1 more source