Results 31 to 40 of about 7,116,689 (296)

Evidence‐Informed Multidisciplinary Consensus Guidance for the Psychosocial Care of Adolescents With High‐Risk Cancer: Recommendations From the Italian Association of Pediatric Hematology and Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adolescents with high‐risk cancer face complex developmental, psychosocial, and ethical challenges that extend beyond disease‐directed treatment. Although international recommendations exist for communication, psychosocial care, pediatric palliative care, survivorship, and shared decision‐making, these have largely evolved within ...
Johanna M. C. Blom, Dorella Scarponi, Giulia Zucchetti, Teresa Perillo, Maria Montanaro, Elisa Marconi, Chiara Rutigliano, Paolo Colavero, Paola Quarello, Marina Bertolotti, Monica Cellini, Carlo Clerici, Maurizio Mascarin, Francesca Bomben, Andrea Ferrari, the expert workgroup   +15 more
wiley   +1 more source

An evaluation of the palliative care-related outcomes of a cohort of TB patients in a district hospital setting: a multiple methods quality improvement study [PDF]

, 2013
Includes bibliographical references.Although curable, tuberculosis (TB) remains a serious health care problem. During 2011 there were almost 9 million new cases and 1.4 million TB deaths worldwide.
Defilippi, Kathleen Mary
core   +1 more source

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source

Using prior information to individualize start item selection when assessing physical functioning with the EORTC CAT Core

Health and Quality of Life Outcomes
Background Computerized adaptive test (CAT) provides individualized measurement, using the patient’s previous responses to select the next most informative item.
Morten Aa. Petersen, Hugo Vachon, Johannes M. Giesinger, Mogens Groenvold, on behalf of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The individual context, and met and unmet palliative care needs of stage III and IV HIV/AIDS isiXhosa speaking patients in the Grahamstown hospice service [PDF]

, 2011
Includes bibliographical references (leaves 87-102).Palliative care developed as a response to the specific needs experienced by terminally ill cancer patients and their families.
Matthews, Barbara
core   +1 more source

POSSIBILITIES OF SYSTEMIC RADIONUCLIDE THERAPY IN PALLIATIVE TREATMENT OF P ATIENTS WITH METASTATIC BONES DISEASE

Исследования и практика в медицине, 2015
The pain syndrome accompanying metastatic damage of bones, significantly reduces quality of patients life. In recent decades, medical practice implemented methods systemic radionuclide therapy of bone metastases using different radionuclides, which ...
A. D. Kaprin, A. A. Kostin, A. V. Leontyev, T. N. Lazutina, I. V. Pylova, L. V. Dushakova   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Equity, need and access in health care: a mixed methods investigation of specialist palliative care use in relation to age [PDF]

, 2010
The equitable provision of care is a core principle of the NHS. Previous research suggests that older cancer patients may be less likely to use specialist palliative care than younger patients, but studies have failed to fully define and measure clinical
Burt, J.A.
core