Results 61 to 70 of about 746,560 (254)
Advanced Science, EarlyView.Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao +11 more
wiley +1 more source
Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells
Advanced Science, EarlyView.ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen +11 more
wiley +1 more source
Information Aggregation in Exponential Family Markets
, 2014 We consider the design of prediction market mechanisms known as automated market makers. We show that we can design these mechanisms via the mold of \emph{exponential family distributions}, a popular and well-studied probability distribution template ...
Chen Yiling +8 more
core +1 more source
Advanced Science, EarlyView.We delineate a TGFβ1/SMAD/lnc‐APUE/E‐cadherin axis wherein TGFβ1 signaling activates lnc‐APUE; lnc‐APUE subsequently downregulates E‐cadherin expression via Alu element‐driven STAU1‐mediated decay of CDH1 mRNA, thereby promoting tumor metastasis. Our findings reveal a novel regulatory function for lnc‐APUE within the SMD pathway, elucidate a distinct ...
Song‐Yang Li +10 more
wiley +1 more source
Ateliers d'Anthropologie, 2013 This article aims to show how Palo Monte ritual identity is created, by focusing on the processes that allow a person to be considered a rightful initiate.
Katerina Kerestetzi
doaj +1 more source
Agronomy, 2020 Mixed crop−livestock long-term experiments (LTE) are critical to increase the understanding of sustainability in complex agroecosystems. One example is the ‘Palo a Pique’ LTE which has been running for 25 years in Uruguay (from 1995 to ...
Pablo Rovira +6 more
doaj +1 more source
Resilient Calvarial Bone Marrow Supports Retinal Repair in Type 2 Diabetes
Advanced Science, EarlyView.Skull bone (calvarium) marrow in diabetic mice stay structurally intact and keeps making blood cells, unlike the bone marrow of the leg bones. The skull marrow is exposed to cerebrospinal fluid (CSF), which contains protective molecules called oxysterols.
Bright Asare‐Bediako +16 more
wiley +1 more source
University Partnerships With Community Change Initiatives: Lessons Learned From the Technical Assistance Partnerships of the William and Flora Hewlett Foundation's Neighborhood Improvement Initiative [PDF]
, 2002 Examines the specific role of students and faculty in providing responsive research, technical assistance, and evaluation supports to the community.
Julia Parzen
core
Screw‐Based Pill for Intelligent Robotic Extraction of Viscous Fluids in Medical Applications
Advanced Intelligent Systems, EarlyView.Screw‐based pill for intelligent robotic extraction (S‐PIRE) is a magnetically actuated smart capsule with a motorized screw, 3‐axis sensor, and Bluetooth control for site‐specific and minimally invasive remote sampling of viscous fluids, overcoming passive diffusion limitations.
Prima Dewi Sinawang +6 more
wiley +1 more source
On Path Integral Localization and the Laplacian
, 1998 We introduce a new localization principle which is a generalized canonical transformation. It unifies BRST localization, the non-abelian localization principle and a special case of the conformal Duistermaat-Heckman integration formula of Paniak ...
Topi Kärki, Witten E.
core +3 more sources