Results 151 to 160 of about 139,986 (260)

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

Clinical Pharmacology &Therapeutics, EarlyView.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra, Viktoriia Starokozhko, Elisabeth Bakker, Anna Maria Gerdina Pasmooij, Peter Gerardus Maria Mol   +4 more
wiley   +1 more source

Cranial nerve neuropathies: a rare manifestation of cat scratch disease. [PDF]

BMC Infect Dis
Yakubovsky M, Kosman A, Kadar L, Paran Y, Grisaru-Soen G, Gadoth A, Yahav D, Ben-Ami R, Strahilevitz J, Zimhony O, Ephros M, Giladi M.   +11 more
europepmc   +1 more source

Family's socioeconomic and demographic factors on elements of children's dental and oral health: A scoping review

Clinical and Experimental Dental Research, EarlyView.
Abstract Background Family plays a significant role in children's dental and oral health (DOH) elements, such as children's DOH knowledge and practice, the development of children's dental fear and anxiety (DFA), children's dental visits, and children's DOH status.
Wisnu Fadila, Mugia B. Rahardja, Puguh Prasetyoputra, Anne A. Suwargiani, Yanu E. Prasetyo, Eriska Riyanti   +5 more
wiley   +1 more source

A Case Report of Familial Facial Nerve Palsy in an Infant. [PDF]

Cureus
Stevens D, Laxton SJ, Woods D.
europepmc   +1 more source

Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

Developmental Dynamics, EarlyView.
Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell, Tracy Eng, Jeffrey D. Amack, David Pruyne   +3 more
wiley   +1 more source

Risk factors for pregnancy-associated Bell's palsy: A nationwide population-based register study. [PDF]

Acta Obstet Gynecol Scand
Lansing L, Marsk E, Wendel SB.
europepmc   +1 more source

Reduced Oligodendrocyte Density and Axonal Caliber Associated With Mitochondrial Alterations in the White Matter of Chronically‐Starved Mice

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe eating disorder associated with extreme weight loss, hyperactivity, and amenorrhea. Neuroimaging studies revealed brain atrophy and disruption of white matter integrity in the corpus callosum (CC) of patients with AN. However, the underlying pathophysiological mechanisms remain unclear.
Stephan Lang, Annelie Zimmermann, Kaja Dickert, Hanna Rupprecht, Julia Priebe, Fabienne Haberland, Hanna‐Sophia Henschke, Katharina Schuster, Marcus Frank, Linda Frintrop   +9 more
wiley   +1 more source

Contralateral mononostril endoscopic chopsticks technique for an intracavernous epidermoid cyst. Technical case report and systematic review of the literature. [PDF]

Brain Spine
Ferlendis L, Fava A, Chainey J, Passeri T, Justo J, Froelich S.   +5 more
europepmc   +1 more source

Pseudoaneurysms as a complication of stereoelectroencephalography: Case series and clinical recommendations

Epilepsia, EarlyView.
Abstract Objective Stereoelectroencephalography (sEEG) is commonly employed in the workup for epilepsy surgery in patients with focal drug‐resistant epilepsy (DRE). Intracranial hemorrhage is a known complication, with reported incidence rates ranging from .9% to 19.1%. Rarely, pseudoaneurysms have been reported in literature as a potential cause. This
Youssra El Khou, Rick H. G. J. van Lanen, G. Louis Wagner, Simon Tousseyn, Gwendolyn de Bruyn, Christianne M. C. Hoeberigs, Bart A. J. M. Wagemans, Christiaan van der Leij, Sylvia Klinkenberg, Jeske Nelissen, Pieter L. Kubben, Olaf E. M. G. Schijns, Jim T. A. Dings, Kim Rijkers, on behalf of the ACE Epilepsy Surgery group, Gwendolyn de Bruyn, Albert Colon, Jim Dings, Marc Hendriks, Danny Hilkman, Christianne Hoeberigs, Jochem van der Pol, Lotte de Jong, Kim Rijkers, Sylvia Klinkenberg, Vivianne van Kranen Mastenbroek, Jeske Nelissen, Pieter Kubben, Walter M. Palm, Rob P. W. Rouhl, Olaf Schijns, Simon Tousseyn, Marielle Vlooswijk, Louis Wagner, Dorien Weckhuysen, Ilse van Straaten   +35 more
wiley   +1 more source

Delayed Recovery From Radiation-Induced Oculomotor Nerve Palsy. [PDF]

J Clin Neurol
Kim H, Hwang K, Choi JY, Kim JS.
europepmc   +1 more source