Results 31 to 40 of about 6,776 (216)

Sandwich immunoassay for adrenomedullin precursor and its practical application

Scientific Reports
Adrenomedullin (ADM) is a multifaceted peptide hormone involved in numerous physiological processes, including vascular stability, vasodilation, angiogenesis, and anti-inflammatory responses.
Paul Kaufmann, Yulia Ilina, Michaela Press, Andreas Bergmann   +3 more
doaj   +1 more source

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran, Malo Gaubert, Alice Dufey, Elise Bannier, Audrey Rico, Jean‐Christophe Ferré, Raphaël Chouteau, Laure Michel, Emmanuelle Le Page, Virginie Callot, Bertrand Audoin, Sarah Demortière, Benoît Combès, Anne Kerbrat   +13 more
wiley   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

The Proposed Warehouse Improvement Using Lean Approach to Eliminate Waste at the Main Warehouse of PT. XYZ

OPSI, 2023
One of the grocery companies in Indonesia provides a multi-channel e-groceries digital platform for online daily shopping activities. One of the important elements that support the operational activities of an e-commerce service industry is the warehouse,
Danaswara Amara Dhika, Amal Witonohadi, Annisa Dewi Akbari   +2 more
doaj   +1 more source

Impact of N-terminal domain on the sHSP Lo18 function

Scientific Reports
External stress conditions can induce disturbances in the internal environment of cells, sufficient for protein misfolding or membrane disorganization.
Tiffany Bellanger, Camille Eicher, Fabien Garces, Amélie Cresson, Cosette Grandvalet, Hervé Alexandre, Stéphanie Weidmann   +6 more
doaj   +1 more source

High Health Care Utilization Preceding Diagnosis With Juvenile Idiopathic Arthritis

Arthritis Care &Research, EarlyView.
Objective Although early diagnosis improves long‐term outcomes, patients with juvenile idiopathic arthritis (JIA) often experience prolonged, circuitous paths to diagnosis. To inform diagnostic improvement, we sought to characterize health care utilization in the year preceding diagnosis. Methods We identified 10,021 patients with an incident diagnosis
Anna Costello, Rui Xiao, Xuemei Zhang, Jahan Jazayeri, Irit R. Rasooly, Pamela F. Weiss   +5 more
wiley   +1 more source

Planejamento e sustentabilidade urbana: uma análise do Plano de Ação da Macrometrópole Paulista

Revista Brasileira de Meio Ambiente, 2020
O artigo visa a analisar o Plano de Ação da Macrometrópole Paulista (PAM), elaborado pela Empresa Paulista de Planejamento Metropolitano S.A – EMPLASA previsto para o período de 2013-2040, sob o olhar da Sustentabilidade Urbana crítica.
Gabriel Pires de Araújo, Letícia Stevanato Rodrigues, Beatriz Duarte Dunder, Silvia Helena Zanirato   +3 more
doaj  

Impact of Government Policy on Tuna Commodities in Malang District, East Java

Habitat, 2020
Tuna commodity turns out to be one of fishery commodities contributing to an export increase by value above the average of 18.57%. This is an opportunity for Indonesia to improve the country's economy by utilizing existing fishery resources.
Yeni Sari Wulandari, Suhartini Suhartini, Hery Toiba   +2 more
doaj   +1 more source

Safety of Prescription Nonsteroidal Anti‐inflammatory Drugs in Adults With Inflammatory Bowel Disease: Data From a Large Administrative Claims Cohort

Arthritis Care &Research, EarlyView.
Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer, Rui Xiao, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +4 more
wiley   +1 more source