Results 91 to 100 of about 19,195 (194)

Novel Pyrazolo [1,5‐a]−1,3,5‐Triazine Derivatives as CDK7 Inhibitors: Synthesis and Biological Insights in Pancreatic Ductal Adenocarcinoma Models

ChemMedChem, Volume 20, Issue 19, October 6, 2025.
Pyrazolo [1,5‐a]−1,3,5‐triazine derivatives efficiently synthesized showed remarkable cytotoxicity and inhibition of cell migration in PDAC models. They induced apoptosis, upregulated apoptotic gene expression, and disrupted the cell cycle, significantly reducing the viability of spheroidal PATU‐T cultures.
Daniela Carbone, Francesca Terrana, Ludovica Sciuto, Camilla Pecoraro, Geng Xu, Stella Cascioferro, Girolamo Cirrincione, Godefridus J. Peters, Elisa Giovannetti, Barbara Parrino, Patrizia Diana   +10 more
wiley   +1 more source

Paracentral Acute Middle Maculopathy Following Acute Primary Angle Closure and Acute Primary Angle Closure Glaucoma

Clinical Ophthalmology, 2023
Hui Xiao,* Ni Guo,* Junyi Li, Ling Jin, Yuan Liu, Shufen Lin, Lei Fang, Xing Liu, Chengguo Zuo State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and ...
Xiao H, Guo N, Li J, Jin L, Liu Y, Lin S, Fang L, Liu X, Zuo C   +8 more
doaj  

Ergodic Properties of Square-Free Numbers

, 2013
We construct a natural invariant measure concentrated on the set of square-free numbers, and invariant under the shift. We prove that the corresponding dynamical system is isomorphic to a translation on a compact, Abelian group.
Cellarosi, Francesco, Sinai, Yakov G.
core   +1 more source

Differential impact of manganese on glutamate clearance, electroencephalography, and sleep in Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Underlying glutamate dysregulation in Alzheimer's disease can be worsened by environmental factors like manganese (Mn) exposure. This study examined how excess Mn affects glutamatergic signaling and neurotransmission in a beta‐amyloid mouse model. METHODS APP/PSEN1 and control mice were exposed to systemic Mn subcutaneously.
Rebecca A. Buchanan, Alec T. Kramer, Erin S. Calipari, Aaron B. Bowman, William P. Nobis, Fiona E. Harrison   +5 more
wiley   +1 more source

Paracentral acute middle maculopathy and hemodynamically significant patent foramen ovale

AJO International
Purpose: To report a possible association between paracentral acute middle maculopathy (PAMM) and hemodynamically significant patent foramen ovale (PFO), and to propose a cardiovascular screening strategy for patients with unexplained isolated PAMM ...
Chiara Muzio, Federica Fossataro, Stefano Erba, Stefano De Angelis, Manuela Mambretti, Marco Pisaniello, Marco Nassisi, Giuseppe Casalino, Francesco Viola   +8 more
doaj   +1 more source

A big phylogenomic tree with bigger taxonomic implications for the world's biggest rove beetles (Coleoptera, Staphylinidae, Staphylinini, Platydracus‐group)

Systematic Entomology, Volume 50, Issue 4, Page 1041-1066, October 2025.
The first phylogenomic study of the Platydracus group of rove beetle genera is provided. It targets 1229 loci and 138 taxa with a post‐analysis assessment of morphological characters. This group of 400+ described species is found monophyletic and reclassified into 12 monophyletic genera to give a frame for the badly needed species‐level taxonomy.
Qing‐Hao Zhao, Adam Brunke, José L. Reyes‐Hernández, Aslak Kappel Hansen, Alexey Solodovnikov   +4 more
wiley   +1 more source

Reduced Order Optimal Control of the Convective FitzHugh-Nagumo Equation

, 2019
In this paper, we compare three model order reduction methods: the proper orthogonal decomposition (POD), discrete empirical interpolation method (DEIM) and dynamic mode decomposition (DMD) for the optimal control of the convective FitzHugh-Nagumo (FHN ...
Karasözen, Bülent, Küçükseyhan, Tuğba, Uzunca, Murat   +2 more
core   +1 more source

Optimization of the empirical antibiotic choice during the treatment of acute prosthetic joint infections: a retrospective analysis of 91 patients

Acta Orthopaedica, 2019
Background and purpose — The preferred treatment of an acute prosthetic joint infection (PJI) is debridement, antibiotics, irrigation and retention of the prosthesis (DAIR). The antibiotic treatment consists of an empirical and targeted phase.
Joost H J Van Erp, Adriaan C Heineken, Remco J A Van Wensen, Robin W T M Van Kempen, Johannes G E Hendriks, Marjolijn Wegdam-Blans, Judith M Fonville, M C (Marieke) Van Der Steen   +7 more
doaj   +1 more source

Numerical meshing issues for three-dimensional flow simulation in journal bearings [PDF]

, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
3rd Micro and Nano Flows Conference (MNF2011), Nobis, M, Schmidt, M, Stücke, P   +3 more
core  

Computational morphogenesis of free form shells: Filter methods to create alternative solutions [PDF]

, 2009
p. 536-547Actual trends in numerical shape optimal design of structures deal with handling of very large dimensions of design space. The goal is to allowing as much design freedom as possible while considerably reducing the modelling effort.
BLETZINGER, Kai-Uwe, FIRI, Matthias, LINHARD, Johannes, WÜCHNER, Roland   +3 more
core   +1 more source