Results 71 to 80 of about 19,195 (194)

Pharmacologically directed strategies in academic anticancer drug discovery based on the European NCI compounds initiative [PDF]

, 2017
Background: The European NCI compounds programme, a joint initiative of the EORTC Research Branch, Cancer Research Campaign and the US National Cancer Institute, was initiated in 1993.
A Kamb, AM Burger, Andrew D Westwell, Anne-Sophie Govaerts, AR Hanauske, Cancer Target Discovery and Development Network, CO Leong, E Boven, GG Dark, GM Tozer, Godefridus J Peters, Hans R Hendriks, HH Fiebig, HR Hendriks, I Fichtner, I Fichtner, Iduna Fichtner, IV Bijnsdorp, J Mantaj, J Plowman, JI Johnson, K Bonezzi, KD Paull, M Hollingshead, M Seckl, MG Hollingshead, MR Boyd, MR Grever, P Diana, R Schultz, RE Wittes, RM Phillips, Sally Burtles, SL Holbeck, SP Langdon, TD Bradshaw, TD Bradshaw   +36 more
core   +2 more sources

CBP/β‐Catenin Signaling in Hepatocytes Plays Pivotal Roles in MMP‐7‐Mediated Liver Fibrosis in a Metabolic Dysfunction‐Associated Steatohepatitis Mouse Model

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
CDAHFD‐induced hepatic steatosis stimulates CBP/β‐catenin signaling in hepatocytes, leading to increased production of the downstream effector MMP‐7. Hepatocyte‐derived MMP‐7 contributes to fibrogenic responses and is associated with the progression of liver fibrosis.
Jun Imamura, Masamichi Kimura, Yumi Otoyama, Koji Nishikawa, Michinori Kohara, Kiminori Kimura   +5 more
wiley   +1 more source

Critical Review on the Molecular Behavior of Surfactants at the Oil–Water Interface During Oil Displacement

Energy Science &Engineering, Volume 14, Issue 3, Page 1626-1662, March 2026.
This review systematically explores the molecular behavior of diverse surfactants (anionic, cationic, nonionic, amphoteric) at the oil–water interface through molecular dynamics simulations. It highlights their roles in reducing interfacial tension, altering interfacial structure, and enhancing oil recovery efficiency.
Zhaowei Hou, Wenchao Jiang, Xiaolin Wu, Jian Gai, Liqiang Zheng, Jie Chen, Shuanghua Wang, Shouliang Lu, Bin Huang, Jichao Sun, Long Su   +10 more
wiley   +1 more source

Is There Any Room for Pharmacometrics With Immuno-Oncology Drugs? Input from the EORTC-PAMM Course on Preclinical and Early-phase Clinical Pharmacology

Anticancer Research, 2019
As part of the Pharmacology & Molecular Mechanisms (PAMM) Group, European Organization for Research and Treatment on Cancer (EORTC) 2019 winter Meeting Educational sessions, special focus has been placed on strategies to be undertaken to reduce the ...
A. Rodallec, R. Fanciullino, S. Benzekry, J. Ciccolini   +3 more
semanticscholar   +1 more source

Synthesis and Evaluation of Novel Thermoplastic Elastomers via Anionic Polymerization of Bio‐Based α‐Methyl‐p‐Methylstyrene

Journal of Polymer Science, Volume 64, Issue 3, Page 743-751, 1 February 2026.
Bio‐based PAMMS‐PI‐PAMMS triblock copolymers prepared via sequential anionic polymerization display widely tunable tensile behavior. Variation of the block composition enables systematic control of strength and extensibility, offering a sustainable platform for thermoplastic elastomers. ABSTRACT In this study, we examined novel thermoplastic elastomers
Goki Hattori, Gaishi Murakami, Tomohiro Kubo, Kotaro Satoh   +3 more
wiley   +1 more source

Cilioretinal artery occlusion with paracentral acute middle maculopathy associated with COVID-19

Indian Journal of Ophthalmology, 2021
The purpose of the study is to describe cilioretinal artery (CILRA) occlusion that is presumed to be associated with COVID-19 without severe respiratory distress and inform ophthalmologists of unusual ocular presentations of COVID-19.
Cemal Ozsaygılı, Nurettin Bayram, Hakan Ozdemir   +2 more
doaj   +1 more source

A Brief Guide to Performing Pharmacological Studies In Vitro: Reflections from the EORTC-PAMM Course “Preclinical and Early-phase Clinical Pharmacology”

Anticancer Research, 2019
One aim of cell-based in vitro assays is to identify the best drug candidate to develop using the best tumor cell model. This is challenging in every anticancer drug discovery process.
M. Capula, C. Corno, B. El Hassouni, Giovanna Li Petri, S. Aranđelović   +4 more
semanticscholar   +1 more source

Creating communities that lead to retention : the social worlds and communities of umpires

, 2011
Umpires (referees) are essential for sport competition, yet many sports report difficulty in recruiting and retaining umpires. Therefore, this research sought to better understand what experiences will ensure continued participation in umpiring. Previous
Kellett, Pamm, Warner, Stacy
core   +1 more source

100 years of GAMM: Motivation, history and achievements

ZAMM - Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik, Volume 106, Issue 1, January 2026.
Abstract The International Association of Applied Mathematics and Mechanics (Gesellschaft für Angewandte Mathematik und Mechanik, GAMM) was founded in 1923 with the goal to strengthen the field of scientific engineering by the foundation of an Engineering Association with strong scientific contacts to Applied Mathematics.
Wolfgang Ehlers
wiley   +1 more source

TS Gene Polymorphisms Are Not Good Markers of Response to 5-FU Therapy in Stage III Colon Cancer Patients

Analytical Cellular Pathology, 2010
Aim: Although the predictive and prognostic value of thymidylate synthase (TS) expression and gene polymorphism in colon cancer has been widely studied, the results are inconclusive probably because of methodological differences.
A. Fariña-Sarasqueta, M. J. E. M. Gosens, E. Moerland, I. van Lijnschoten, V. E. P. P. Lemmens, G. D. Slooter, H. J. T. Rutten, A. J. C. van den Brule   +7 more
doaj   +1 more source