Results 111 to 120 of about 220,121 (275)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
"Dissent and Discipline in Ben Gurion's Labor Party: 1930-32" [PDF]
This paper describes a small opposition group that functioned during 1930-33 on the left fringes of Ben Gurion's Mapai party in Palestine. Mapai dominated Jewish Palestine's politics, and later the politics of the young State of Israel; it lives on today
Joel Perlmann
core
Apollo-Soyuz pamphlet no. 3: Sun, stars, in between [PDF]
, 1977 The structure of the sun and its surface temperature and brightness are discussed as background for explaining the ASTP joint experiment to photograph the solar corona from Soyuz while the Apollo spacecraft created an artificial eclipse by blocking out ...
From, T. P., Page, L. W.
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Having a Conversation About Health Care Wishes and Goals in Vermont [PDF]
, 2017 Research has shown that people think talking with family and friends about end-of-life care is important, but they do not actually have this conversation. The majority of adults do not have any form of advance care planning in place.
King, Eric C
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
A Multimodal Approach to Hypertension: Behavioral Modifications on a Budget [PDF]
, 2017 Hypertension is one of the most common diagnoses in the adult population in the United States. Hypertension also has various sequelae that are preventable with adequate treatment, including medication and lifestyle modification.https://scholarworks.uvm ...
Manigrasso, Jayne
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source