Results 71 to 80 of about 220,121 (275)

Apollo-Soyuz pamphlet no. 5: The earth from orbit [PDF]

open access: yes, 1977
Astronaut training in the recognition of various geological features from space is described as well as the cameras, lenses and film used in experiment MA-136 to measure their effectiveness in photographing earth structural features from orbit.
From, T. P., Page, L. W.
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Apollo-Soyuz pamphlet no. 8: Zero-g technology [PDF]

open access: yes, 1977
The behavior of liquids in zero gravity environments is discussed with emphasis on foams, wetting, and wicks. A multipurpose electric furnace (MA-010) for the high temperature processing of metals and salts in zero-g is described.
From, T. P., Page, L. W.
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

”Kampagnen med Blæk i stedet for Blod”: Håndskrifter, trykk og opinionskamp i skandinavisk offentlighet, 1801–1814

open access: yesSjuttonhundratal, 2017
“The campaign with ink instead of blood”: Manuscripts, print and the war of opinion in the Scandinavian public sphere, 1801–1814 Handwritten pamphlets circulated to a high extend as part of the war of opinion which went on in the Norwegian-Swedish ...
Ruth Hemstad
doaj   +1 more source

Apollo Soyuz pamphlet No. 7: Biology in zero-G [PDF]

open access: yes, 1977
The effects of weightlessness on small living organisms, and methods for improving biological techniques were investigated in the seven experiments reported in this pamphlet which is intended as a curriculum supplement for secondary schools.
Page, L. W., Page, T.
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Guide to the Chateau Benoit Collection [PDF]

open access: yes, 2018
This collection is comprised of a large variety of publications, documents, photographs, books, and other materials from Fred and Mary Benoit’s time as owners of Chateau ...
Linfield College Archives
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

La haine comme catégorie esthétique

open access: yesRevue Italienne d'Etudes Françaises, 2017
L’article propose de considérer la haine comme une valeur esthétique, non point pour la réhabiliter moralement, mais pour montrer qu’une haine extrême fonctionne comme une œuvre d’art, autotélique et autosuffisante.
Jan Miernowski
doaj   +1 more source

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