Results 21 to 30 of about 817 (214)
Nature Methods, 2020 Structure-guided engineering allows researchers access to an expanding number of Cas9 variants that relax the constraint imposed by target site recognition of a protospacer-adjacent motif (PAM).
openaire +2 more sources
Are AMPA Receptor Positive Allosteric Modulators Potential Pharmacotherapeutics for Addiction?
Pharmaceuticals, 2013 Positive allosteric modulators (PAMs) of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are a diverse class of compounds that increase fast excitatory transmission in the brain.
Lucas R. Watterson, M. Foster Olive
doaj +1 more source
Shape Effects of Peptide Amphiphile Micelles for Targeting Monocytes
Molecules, 2018 Peptide amphiphile micelles (PAMs) are a nanoparticle platform that have gained popularity for their targeting versatility in a wide range of disease models.
Johan Joo +3 more
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RNA-sequence analysis of primary alveolar macrophages after in vitro infection with porcine reproductive and respiratory syndrome virus strains of differing virulence. [PDF]
PLoS ONE, 2014 Porcine reproductive and respiratory syndrome virus (PRRSV) mainly infects porcine alveolar macrophages (PAMs), resulting in porcine reproductive and respiratory syndrome (PRRS) in pigs.
Bouabid Badaoui +6 more
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Variable Stiffness Structures Utilizing Pneumatic Artificial Muscles
MATEC Web of Conferences, 2019 Pneumatic artificial muscles (PAMs) can offer excellent force-to-weight ratios and act as shape-changing actuator under injecting the actuation fluid into their bladders. PAMs could be easily utilized for morphing structures due to their millimeter-scale
Ning Feng, Chang Yingli, Wang Jingze
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OryxThe Ngezi–Vumawimbi Forest Reserve is the largest remaining patch of natural vegetation on Pemba Island, Zanzibar, Tanzania. In 2024, in collaboration with the Department of Forestry, Ministry of Agriculture, Zanzibar, we conducted a baseline ...
Simone Orsenigo +5 more
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Initiator enhancement of mandrel degradation for ICF target fabrication
iScience, 2022 Summary: Poly-α-methylstyrene (PAMS), as an ideal mandrel material used in the fabrication of inertial confinement fusion (ICF) targets, its efficient degradation is the key to the quality of targets.
Qiang Chen +5 more
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Case Report: 2-PAM or not 2-PAM
Clinical Practice and Cases in Emergency MedicineIntroduction: Organophosphates (OP) are used as pest control agents worldwide and have been seen in accidental and intentional poisonings. Case Report: A patient presented after intentional ingestion of the OP Orthene (50% acephate). Due to copious secretions, the patient was intubated and given atropine by the paramedic before transport.
Huttner, Madelyn +3 more
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Discover MedicineBackground Type 1 Gaucher disease (GD) is a lysosomal storage disorder characterized by splenomegaly, lipid-laden macrophage accumulation (Gaucher cells), and complex skeletal involvement, though its pathophysiology remains incompletely understood.
Meriem Daho +9 more
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SpRY greatly expands the genome editing scope in rice with highly flexible PAM recognition
Genome Biology, 2021 Background Plant genome engineering mediated by various CRISPR-based tools requires specific protospacer adjacent motifs (PAMs), such as the well-performed NGG, NG, and NNG, to initiate target recognition, which notably restricts the editable range of ...
Ziyan Xu +9 more
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