Results 161 to 170 of about 3,204,397 (250)

Exploring Synergistic Combinations in Extended and Pan-Drug Resistant (XDR and PDR) Whole Genome Sequenced Acinetobacter baumannii. [PDF]

Microorganisms, 2023
Quraini MA, Jabri ZA, Sami H, Mahindroo J, Taneja N, Muharrmi ZA, Busaidi IA, Rizvi M.   +7 more
europepmc   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Resensitizing the Untreatable: Zidovudine and Polymyxin Combinations to Combat Pan-Drug-Resistant <i>Klebsiella pneumoniae</i>. [PDF]

Pharmaceuticals (Basel)
Kaur JN, Klem JF, Hailu GS, Nasief NN, Liu Y, Hanna A, Chen A, Holden P, Kapoor S, Smith NM, Sutton M, Li J, Tsuji BT.   +12 more
europepmc   +1 more source

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

Advanced Science, EarlyView.
Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, an sonothermal‐responsive platform has been developed through constructing metal‐semiconductor interface on implants. Biofilm infection and deep vein thrombosis can be successfully treated by controllable ultrasound treatments.
Zhengdong Zhang, Pan Liu, Jie Lei, Shuchang Peng, Qiu Chen, Wei Guan, Yizhou Zhu, Gang Liu, Xiaobo Feng, Cao Yang, Lei Tan   +10 more
wiley   +1 more source

Genomic Characterization of Pan-Drug Resistant Klebsiella pneumoniae KPNW Isolated From UTI Patient in Bangladesh. [PDF]

Microbiologyopen
Murad MW, Poran GMS, Baidya K, Ahsan N.
europepmc   +1 more source

Bacteriophage Therapy for Pan-Drug-Resistant <i>Pseudomonas aeruginosa</i> in Two Persons With Cystic Fibrosis. [PDF]

J Investig Med High Impact Case Rep, 2023
Hahn A, Sami I, Chaney H, Koumbourlis AC, Del Valle Mojica C, Cochrane C, Chan BK, Koff JL.   +7 more
europepmc   +1 more source

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

Biosynthetic ε-poly-L-lysine for the treatment of extensively- and pan-drug-resistant Pseudomonas aeruginosa. [PDF]

NPJ Antimicrob Resist
Ting DSJ, Aung TT, Mayandi V, Periayah MH, Goh ETL, Muthu M, Barathi VA, Mehta JS, Tan DTH, Lakshminarayanan R.   +9 more
europepmc   +1 more source

Identification and Characterization of vB_PreP_EPr2, a Lytic Bacteriophage of Pan-Drug Resistant Providencia rettgeri. [PDF]

Viruses, 2022
Mencke JL, He Y, Filippov AA, Nikolich MP, Belew AT, Fouts DE, McGann PT, Swierczewski BE, Getnet D, Ellison DW, Margulieux KR.   +10 more
europepmc   +1 more source

Root‐Inspired Microneedle Patch With Interlocked Rigid‐Soft Architecture for High Tissue‐Adaptiveness

Advanced Science, EarlyView.
A root‐inspired microneedle array patch uses lattice‐based mechanical interlocking to unite rigid microneedles with a flexible substrate. The interlocked rigid–soft architecture improves interfacial bonding, supports stable adhesion on curved and wet tissues under dynamic motion, and provides a versatile platform for robust biointerfacing and future ...
Jongchan Lee, Yeongjun Song, Yonghyun Cho, Hyo In Kim, Dong‐Hyun Youn, Jinbong Park, Seungbeom Choi, Dohyun Kwon, Brian Jun Lee, Sangyul Baik   +9 more
wiley   +1 more source