Results 41 to 50 of about 3,204,397 (250)

Pathogenic spectrum of blood stream infections and resistance pattern in Gram-negative bacteria from Aljouf region of Saudi Arabia.

PLoS ONE, 2020
BackgroundThe pathogenic spectrum of bloodstream infections (BSIs) varies across regions. Monitoring the pathogenic profile and antimicrobial resistance is a prerequisite for effective therapy, infection control and for strategies aimed to counter ...
Altaf Bandy, Abdulrahman Hamdan Almaeen
doaj   +1 more source

Heterogeneity of Antibiotics Multidrug-Resistance Profile of Uropathogens in Romanian Population

Antibiotics, 2021
Urinary tract infections (UTIs) are a leading cause of morbidity for both males and females. The overconsumption of antibiotics in general medicine, veterinary, or agriculture has led to a spike in drug-resistant microorganisms; obtaining standardized ...
Răzvan-Cosmin Petca, Silvius Negoiță, Cristian Mareș, Aida Petca, Răzvan-Ionuț Popescu, Călin Bogdan Chibelean   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

New emerging drug-resistant malaria

, 2010
Viroj WiwanitkitWiwanitkit House, Bangkhae, Bangkok ThailandDate of preparation: 20th August 2008Conflict of interest: None declaredClinical question: What is the best treatment for artemisinin-resistant malaria?Results: There is still no better ...
Viroj Wiwanitkit
core   +1 more source

Special Issue on Nano-Systems for Antimicrobial Therapy

Applied Sciences, 2019
Antibacterial materials and surfaces designed and built using the toolbox of nanotechnology are becoming the object of an increasingly boosting interest, responding to the pan-drug resistant bacteria emergency [...]
Giacomo Dacarro, Angelo Taglietti
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Diagnosis and Interim Treatment Outcomes from the First Cohort of Multidrug-Resistant Tuberculosis Patients in Tanzania. [PDF]

, 2013
Kibong'oto National Tuberculosis Hospital (KNTH), Kilimanjaro, Tanzania. Characterize the diagnostic process and interim treatment outcomes from patients treated for multidrug-resistant tuberculosis (MDR-TB) in Tanzania.
Kumburu Happiness H., Ndusilo, N.D., Boeree, M.J., Kibiki, Gibson S, Mpagama Stellah G., Kumburu, Happiness H, Houpt, Eric R, Heysell, Scott K, Eric R Houpt, Boeree Martin J., Kisonga, Riziki M, Kibiki, G.S., Nora D Ndusilo, Jean Gratz, Ndusilo Nora D., Riziki M Kisonga, Boeree, Martin J, Lekule Isack A., Stellah G Mpagama, Martin J Boeree, Heysell, S.K., Kisonga Riziki M., Mpagama, Stellah G, Ndusilo, Nora D, Kumburu, H.H., Scott K Heysell, Lekule, Isack A, Gratz, J., Kisonga, R.M., Gratz, Jean, Kibiki Gibson S., Houpt, E.R., Gibson S Kibiki, Heysell Scott K., Mpagama, S.G., Lekule, I.A., Houpt Eric R., Isack A Lekule, Gratz Jean, Happiness H Kumburu   +39 more
core   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Acinetobacter species meningitis in children: a case series from Karachi, Pakistan

Journal of Infection in Developing Countries, 2011
Introduction: Multidrug-resistant strains of Acinetobacter pose a serious therapeutic dilemma in hospital practice, particularly when they cause meningitis, as the few antimicrobial agents to which these isolates are susceptible have poor central ...
Ali Faisal Saleem, Muhammad Shafaat Shah, Abdul Sattar Shaikh, Fatima Mir, Anita K M Zaidi   +4 more
doaj   +1 more source