Results 121 to 130 of about 846,489 (348)

Obstructive Jaundice as a Complication of Macrocystic Serous Cystadenoma of the Pancreas

Acta Medica Indonesiana, 2016
Macrocystic serous cystadenoma is an unusual and essentially benign pancreatic tumor. Herein, we report on a 40-year-old woman diagnosed with macrocystic serous cystadenoma who presented with obstructive jaundice.
Hendra Koncoro, I Komang WD Putra, I Dewa N Wibawa   +2 more
doaj   +2 more sources

Nortriptyline Inhibits Lysosomal Exocytosis‐Mediated SASP During Gastric Cancer Progression via Targeting HOXA1‐PITX2 Phase Separation

Advanced Science, EarlyView.
This study identifies that HOXA1 facilitates transcriptional activity of PITX2 in liquid condensates, resulting in up‐regulation of MCOLN1 and RAB3A followed by lysosomal exocytosis of LGALS1 and IGFBP7 from senescent cells, thus activating AKT signaling and EMT.
Yi Zhou, Chunhui Yang, Xinyue Li, Xiaojing Wang, Wanju Jiao, Xiaolin Wang, Jiaying Qu, Bosen Zhao, Shunchen Zhou, Qiangsong Tong, Liduan Zheng   +10 more
wiley   +1 more source

Pancreatic function and gene deletion F508 in cystic fibrosis. [PDF]

, 1990
G Borgo, G. Mastella, Paolo Gasparini, A Zorzanello, Riccardo Doro, P. F. Pignatti   +5 more
openalex   +1 more source

Extracellular Vesicle‐Packaged circTAX1BP1 from Cancer‐Associated Fibroblasts Regulates RNA m6A Modification through Lactylation of VIRMA in Colorectal Cancer Cells

Advanced Science, EarlyView.
This study reveals that CAFs‐derived EVs enriched with circTAX1BP1 drive CRLM by promoting VIRMA lactylation and SP1/TGF‐β signaling, creating a positive feedback loop via ITGA11+ myCAFs. Targeting EV‐circTAX1BP1 and TGF‐β disrupts this loop, offering a novel therapeutic strategy for CRLM.
Jia‐nan Tan, Jin‐hao Yu, Dong Hou, Ye‐quan Xie, Dong‐ming Lai, Fang Zheng, Bin Yang, Jin‐tao Zeng, Yang Chen, Shu‐hong Lu, Guang‐yu Zhong, Fang‐hai Han, Sheng‐ning Zhou   +12 more
wiley   +1 more source

Multidisciplinary diagnostic and therapeutic approaches to pancreatic cystic lesions

Journal of Multidisciplinary Healthcare, 2014
Michael J Clores, Amar Thosani, Jonathan M BuscagliaDivision of Gastroenterology, Department of Medicine, Stony Brook University School of Medicine, Stony Brook, NY, USAAbstract: Pancreatic cystic lesions are commonly encountered today with the routine ...
Clores MJ, Thosani A, Buscaglia JM
doaj  

Medicago Sativa L. Saponin‐Driven Lactobacillus Intestinalis Restores Intestinal Stemness in Naturally Aged Mice via the Bile Acid‐FXR‐Wnt Signaling Axis

Advanced Science, EarlyView.
This study examines the mechanism by which alfalfa saponin (AS) regulates intestinal stemness via modulation of the gut microbiota. The results indicate that AS significantly increases the abundance of Lactobacillus intestinalis, which subsequently activates Wnt signaling via bile acid metabolism and enhances intestinal stemness. These findings provide
Mengqi Liu, Jiamin Sun, Zuyang Jia, Yalei Cui, Xiaoyan Zhu, Zhichang Wang, Hao Sun, Boshuai Liu, Yinghua Shi   +8 more
wiley   +1 more source

Next-generation sequencing of pancreatic cyst wall specimens obtained using micro-forceps for improving diagnostic accuracy. [PDF]

Endosc Int Open, 2023
Astbury S, Baskar A, Grove JI, Kaye P, Aravinthan AD, James MW, Clarke C, Aithal GP, Venkatachalapathy SV.   +8 more
europepmc   +1 more source

Cystic Fibrosis of the Pancreas: Involvement of MUC6 Mucin in Obstruction of Pancreatic Ducts [PDF]

, 1997
Colm J. Reid, Karen Hyde, Samuel B. Ho, Ann Harris, D. J. Weatherall   +4 more
openalex   +1 more source

Essential Updates 2023/2024: Minimally Invasive Surgery for Biliary Tract Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Minimally invasive surgery (MIS) for biliary tract cancer (BTC) has gained traction with advancements in laparoscopic and robotic techniques. However, its oncological impact remains uncertain. This review highlights key studies from 2023 and 2024 on MIS for BTC, including distal bile duct, hilar bile duct, gallbladder, and intrahepatic bile ...
Osamu Itano, Takuya Minagawa
wiley   +1 more source

Single Fusion Pore Analysis via Single Cell Amperometry Uncovers Impaired Pore Expansion That Restricts Insulin Exocytosis in Human Type 2 Diabetes

Angewandte Chemie, EarlyView.
The final step in insulin exocytosis from pancreatic beta cells is the formation of the fusion pore. We combined single‐cell amperometry with microsensors and fluorescence microscopy to monitor insulin exocytosis from different perspectives. Our results reveal a link between impaired fusion pore function and diminished insulin secretion, highlighting ...
Amir Hatami, Nikhil R. Gandasi, Haiqiang Dou, Lakshmi Kothegala, Lena Eliasson, Andrew Ewing, Patrik Rorsman   +6 more
wiley   +2 more sources