Results 51 to 60 of about 10,302,641 (371)
Pancreatic cancer organoids recapitulate disease and allow personalized drug screening
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance We describe a biobank of patient-derived pancreatic cancer organoids, characterized by whole-genome DNA sequencing, RNA sequencing, and histology.
E. Driehuis +28 more
semanticscholar +1 more source
Pancreatic Cancer: Pathogenesis, Screening, Diagnosis and Treatment.
Gastroenterology, 2022 Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer, due to both its late stage at diagnosis and its resistance to chemotherapy. However, recent advances in our understanding of the biology of PDAC have revealed new opportunities ...
L. Wood, M. Canto, E. Jaffee, D. Simeone
semanticscholar +1 more source
Frontiers in OncologyBackgroundPancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors. Most patients are diagnosed at advanced or metastatic stages, losing the opportunity for curative surgery.
Jiuliang Yan +17 more
doaj +1 more source
BMC Cancer, 2022 Background Prognosis for patients recurred rapidly after resection of pancreatic ductal adenocarcinoma (PDAC) was extremely poor. We proposed the concept of postoperative hyper-progression disease (PO-HPD) to define recurrence within 2 months after ...
Siyi Zou +9 more
doaj +1 more source
miRNAs as Regulators of Antidiabetic Effects of Fucoidans [PDF]
, 2019 open access articleDiabetes mellitus is a metabolic disease with a high mortality rate worldwide. MicroRNAs (miRNAs), and other small noncoding RNAs, serve as endogenous gene regulators through binding to specific sequences in RNA and modifying gene ...
Arroo, R. R. J. +8 more
core +1 more source
Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression [PDF]
, 2017 Gastrointestinal cancer is a group of tumors that affect multiple sites of the digestive system, including the stomach, liver, colon and pancreas. These cancers are very aggressive and rapidly metastasize, thus identifying effective targets is crucial ...
Bacigalupo, Maria Lorena +2 more
core +1 more source
Systematic Characterization of the Clinical Relevance of KPNA4 in Pancreatic Ductal Adenocarcinoma
Frontiers in Oncology, 2022 BackgroundPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies with poor prognosis. Karyopherin subunit alpha 4 (KPNA4) is a nuclear transport factor and plays tumor-promoting roles in multiple cancers.
Jingpiao Bao +14 more
doaj +1 more source
Common Pancreatic Disease [PDF]
, 2010 Pancreatitis is an inflammatory disease of the pancreas characterized by acute and chronic condition as well as varying duration and severity. Acute pancreatitis (AP) is a severe abdominal inflammation, characterized by parenchymal edema, necrosis with occasional presence of pseudocysts, abscess, hemorrhage, and inflammatory cell infiltration.
openaire +2 more sources
Alternative polyadenylation of ZEB1 promotes its translation during genotoxic stress in pancreatic cancer cells [PDF]
, 2017 Pancreatic ductal adenocarcinoma (PDAC) is characterized by extremely poor prognosis. The standard chemotherapeutic drug, gemcitabine, does not offer significant improvements for PDAC management due to the rapid acquisition of drug resistance by patients.
Bielli, Pamela +7 more
core +2 more sources
Diabetes, 2014 Circulating immunoreactive trypsinogen (IRT), a biomarker of exocrine pancreatic disease in cystic fibrosis (CF), is elevated in most CF newborns. In those with severe CF transmembrane conductance regulator (CFTR) genotypes, IRT declines rapidly in the ...
David Soave +11 more
semanticscholar +1 more source