Results 61 to 70 of about 646,520 (340)

Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response. [PDF]

, 2015
The majority of those who drink excessive amounts of alcohol do not develop pancreatic disease. One overarching hypothesis is that alcohol abuse requires additional risk factors, either environmental or genetic, for disease to occur.
Lugea, Aurelia, Pandol, Stephen J, Waldron, Richard T   +2 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Clinical‐radiological characteristics and intestinal microbiota in patients with pancreatic immune‐related adverse events

Thoracic Cancer, 2021
Background The pancreatic immune‐related adverse event (irAE) is a rare but increasingly occurrence disease with limited knowledge, which was associated with the use of immune checkpoint inhibitors (ICIs).
Bei Tan, Min‐jiang Chen, Qi Guo, Hao Tang, Yue Li, Xin‐miao Jia, Yan Xu, Liang Zhu, Meng‐zhao Wang, Jia‐ming Qian   +9 more
doaj   +1 more source

Advantage of oncological outcome of robotic-assisted pancreatoduodenectomy (RPD) in stage I pancreatic ductal adenocarcinomas (PDAC)

Journal of Pancreatology, 2022
Background:. Robotic-assisted pancreatoduodenectomy (RPD) has been widely performed in the treatment of pancreatic tumors. The oncologic outcome in the early stage of pancreatic ductal adenocarcinomas (PDAC) operated by RPD has not been evaluated ...
Jingfeng Li, Shulin Zhao, Jiabin Jin, Yusheng Shi, Yuanchi Weng, Mengmin Chen, Hao Chen, Zhiwei Xu, Xiaxing Deng, Baiyong Shen, Chenghong Peng   +10 more
doaj   +1 more source

STUDIES IN PANCREATIC DISEASE [PDF]

Archives of Internal Medicine, 1915
PART I.—DUODENAL CONTENT ANALYSES AS AN INDEX OF DISEASE, AND FUNCTIONAL ACTIVITY OF THE PANCREAS A reliable method for ascertaining the functional activity of the pancreas, has been eagerly sought for the last few decades, in fact since the time that Kuntzman, Richard Bright and Claude Bernard first called attention to this gland as a possible focus ...
openaire   +2 more sources

Quality of Life in Chronic Pancreatitis is Determined by Constant Pain, Disability/Unemployment, Current Smoking, and Associated Co-Morbidities [PDF]

, 2017
OBJECTIVES: Chronic pancreatitis (CP) has a profound independent effect on quality of life (QOL). Our aim was to identify factors that impact the QOL in CP patients.
Abberbock, Judah, Alkaade, Samer, Amann, Stephen T., Anderson, Michelle A., Baillie, John, Banks, Peter A., Brand, Randall E., Conwell, Darwin L., Cote, Gregory A., Forsmark, Christopher E., Gardner, Timothy B., Gelrud, Andres, Guda, Nalini M., Lewis, Michele D., Machicado, Jorge D., Muniraj, Thiruvengadam, Sandhu, Bimaljit S., Sherman, Stuart, Singh, Vikesh K., Slivka, Adam, Tang, Gong, Whitcomb, David C., Wilcox, C. Mel, Yadav, Dhiraj   +23 more
core   +2 more sources

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

The role of adjuvant chemotherapy for patients with resected pancreatic cancer: Systematic review of randomized controlled trials and meta-analysis [PDF]

, 2007
Background: In patients undergoing surgery for resectable pancreatic cancer prognosis still remains poor. The role of adjuvant treatment strategies (including chemotherapy and chemoradiotherapy) following resection of pancreatic cancer remains ...
Bakkevold KE, Berger AC, Blackstock AW, Cress RD, Donna Pauler Ankerst, Gastrointestinal Tumour Study Group, Hochster HS, Kalser MH, Khanna A, Knaebel HP, Kosuge T, Luttges J, Oettle H, Ozols RF, Peto R, Regine WF, Stefan Boeck, Volker Heinemann   +17 more
core   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Transcriptional control of pancreatic cancer immunosuppression by metabolic enzyme CD73 in a tumor-autonomous and -autocrine manner

Nature Communications, 2023
Cancer cell metabolism contributes to the establishment of an immunosuppressive tumor microenvironment. Aberrant expression of CD73, a critical enzyme in ATP metabolism, on the cell surface results in the extracellular accumulation of adenosine, which ...
Tianyu Tang, Xing Huang, Minghao Lu, Gang Zhang, Xu Han, Tingbo Liang   +5 more
doaj   +1 more source