Results 1 to 10 of about 861,864 (406)

Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip

Nature Biomedical Engineering, 2021
Creating in vitro models of diseases of the pancreatic ductal compartment requires a comprehensive understanding of the developmental trajectories of pancreas-specific cell types.
Sandra Wiedenmann, Markus Breunig, Lucas-Alexander Schulte   +2 more
exaly   +2 more sources

Pancreatic duct size and gland texture are associated with pancreatic fistula after pancreaticoduodenectomy but not after distal pancreatectomy. [PDF]

PLoS ONE, 2018
BACKGROUND:Pancreatic fistula remains a morbid complication after pancreatectomy. Since the proposed mechanism of pancreatic fistula is different between pancreaticoduodenectomy and distal pancreatectomy, we hypothesized that pancreatic gland texture and
Allison N Martin, Sowmya Narayanan, Florence E Turrentine, Todd W Bauer, Reid B Adams, Victor M Zaydfudim   +5 more
doaj   +2 more sources

Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model. [PDF]

Diabetes, 2012
Pancreatic duct glands (PDGs) have been hypothesized to give rise to pancreatic intraepithelial neoplasia (PanIN). Treatment with the glucagon-like peptide (GLP)-1 analog, exendin-4, for 12 weeks induced the expansion of PDGs with mucinous metaplasia and
Butler, Peter C, Dawson, David, Dry, Sarah M, Gier, Belinda, Kirakossian, David, Matveyenko, Aleksey V   +5 more
core   +2 more sources

Endoscopic transpapillary drainage in disconnected pancreatic duct syndrome after acute pancreatitis and trauma: long-term outcomes in 31 patients

BMC Gastroenterology, 2019
Background Conventionally, disconnected pancreatic duct syndrome is treated surgically. Endoscopic management is associated with lesser morbidity and mortality than that observed with surgery and shows similar success rates.
Yan Chen, Yueping Jiang, Wei Qian, Qihong Yu, Yuanhang Dong, Huiyun Zhu, Feng Liu, Yiqi Du, Dong Wang, Zhaoshen Li   +9 more
doaj   +2 more sources

Pancreatic duct patterns in acute pancreatitis: a MRI study. [PDF]

PLoS ONE, 2013
OBJECTIVES: To study the MRI findings of the pancreatic duct in patients with acute pancreatitis. MATERIALS AND METHODS: A total of 239 patients with acute pancreatitis and 125 controls were analyzed in this study.
Rong Peng, Xiao Ming Zhang, Yi Fan Ji, Tian Wu Chen, Lin Yang, Xiao Hua Huang, Xiao Xiao Chi   +6 more
doaj   +2 more sources

A Simple Classification of Pancreatic Duct Size and Texture Predicts Postoperative Pancreatic Fistula

Annals of Surgery, 2021
Objective: The aim of this study was to develop a classification system for pancreas-associated risk factors in pancreatoduodenectomy (PD). Summary Background Data: Postoperative pancreatic fistula (POPF) is the most relevant PD-associated complication ...
F. Schuh, A. Mihaljevic, P. Probst, M. Trudeau, P. Müller, G. Marchegiani, M. Besselink, F. Uzunoglu, J. Izbicki, M. Falconi, C. F. Fernandez-Del Castillo, M. Adham, K. Z'graggen, H. Friess, J. Werner, J. Weitz, O. Strobel, T. Hackert, D. Radenkovic, D. Kelemen, elliot k fishman, Y. Miao, S. Shrikhande, K. Lillemoe, C. Dervenis, C. Bassi, J. Neoptolemos, M. Diener, C. Vollmer, M. Büchler   +29 more
semanticscholar   +1 more source

Pancreatic fibrosis correlates with exocrine pancreatic insufficiency after pancreatoduodenectomy [PDF]

, 2008
Background: Obstruction of the pancreatic duct can lead to pancreatic fibrosis. We investigated the correlation between the extent of pancreatic fibrosis and the postoperative exocrine and endocrine pancreatic function.
Dekken, H. (Herman) van, Eijck, C.H.J. (Casper) van, Hof, G. van 't, Hop, W.C.J. (Wim), Kazemier, G. (Geert), Pek, C.J. (Chulja), Toorenenbergen, A.W. (Albert) van, Tran, T.C.K. (Khe)   +7 more
core   +9 more sources

Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree

eLife, 2021
To study disease development, an inventory of an organ's cell types and understanding of physiologic function is paramount. Here, we performed single-cell RNA-sequencing to examine heterogeneity of murine pancreatic duct cells, pancreatobiliary cells ...
Audrey M Hendley, Arjun A Rao, Laura Leonhardt, Sudipta Ashe, Jennifer A Smith, Simone Giacometti, Xianlu L Peng, Honglin Jiang, David I Berrios, Mathias Pawlak, Lucia Y Li, Jonghyun Lee, Eric A Collisson, Mark S Anderson, Gabriela K Fragiadakis, Jen Jen Yeh, Chun Jimmie Ye, Grace E Kim, Valerie M Weaver, Matthias Hebrok   +19 more
doaj   +1 more source

Enormously dilated pancreatic duct [PDF]

Gut, 2021
A diabetic patient presented with 10 kg weight loss and slightly elevated C reactive protein without diarrhoea, abdominal pain, fever or leucocytosis. Serum lipase, transaminases, bilirubin, carcinoembryonic antigen and CA19-9 were normal. Ultrasound showed prominent perihilar bile ducts and a cystic mass of the pancreas (60×57 mm) with echogenic ...
Ronald Koschny, Matthias Lang, Thilo Hackert   +2 more
openaire   +2 more sources

Severe pancreatic injury with total disruption of main pancreatic duct successfully managed by multi‐stage endoscopic therapy: a case report

Acute Medicine & Surgery, 2022
Background The management of pancreatic injury is not well‐established. Recently, endoscopic therapy has been reported as a treatment option for main pancreatic duct disruption.
Kei Ito, Akira Endo, Masanori Kobayashi, Yasuhiro Otomo   +3 more
doaj   +1 more source