Results 361 to 370 of about 217,476 (395)

Microbiome and pancreatic ductal adenocarcinoma

Clinics and Research in Hepatology and Gastroenterology, 2021
Pancreatic ductal adenocarcinoma (PDAC) incidence and related-deaths are increasing worldwide. PDAC is characterized by poor prognosis due to late diagnosis, high metastatic capacity and resistance to therapy. This is partially due to its specific microenvironment, where the stroma is prominent over tumor cells. Besides the oral and gut microbiota, the
Annemilaï Tijeras-Raballand, Marc Hilmi, Lucile Astorgues-Xerri, Rémy Nicolle, Ivan Bièche, Cindy Neuzillet   +5 more
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Aquaporins in pancreatic ductal adenocarcinoma

APMIS, 2021
Aquaporins are water channel proteins facilitating passive transport of water across cellular membranes. Aquaporins are over‐ or ectopically expressed in a multitude of cancers, including pancreatic ductal adenocarcinoma, which is a highly aggressive cancer with low survival rate. Evidence suggests that aquaporins can affect multiple cellular processes
Bruun-Sørensen, Anne Sofie, E, Sarannya, Login, Frédéric H., Borgquist, Signe, Nejsum, Lene Niemann   +4 more
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Genomics of pancreatic ductal adenocarcinoma

Hepatobiliary & Pancreatic Diseases International, 2014
Pancreatic cancer is one of the worst prognostic cancers because of the late diagnosis and the absence of effective treatment. Within all subtypes of this disease, ductal adenocarcinoma has the shortest survival time. In recent years, global genomics profiling allowed the identification of hundreds of genes that are perturbed in pancreatic cancer.
Christian, Pilarsky, Robert, Grutzmann
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Hypoxia and pancreatic ductal adenocarcinoma

Cancer Letters, 2020
Chemotherapy and immunotherapy for pancreatic ductal adenocarcinoma (PDAC) have limited success. One reason for this is thought to be the cancer microenvironment surrounding PDAC. Hypoxia is a feature of the cancer microenvironment. Under hypoxia, different various molecules and signaling pathways are activated compared with normoxia.
Akio, Yamasaki, Kosuke, Yanai, Hideya, Onishi   +2 more
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Surgery for pancreatic ductal adenocarcinoma

Clinical and Translational Oncology, 2017
Surgical resection is the only potentially curative option in the treatment of pancreatic ductal adenocarcinoma. Preoperative radiological imaging allows to rule out the presence of metastases. Three resectability categories are established based on the radiological findings depending on the degree of contact between the tumor and the blood vessels ...
R. Vera, L. Díez, E. Martín Pérez, J. C. Plaza, A. Sanjuanbenito, A. Carrato   +5 more
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Perineural Invasion Reprograms the Immune Microenvironment through Cholinergic Signaling in Pancreatic Ductal Adenocarcinoma

Cancer Research, 2020
These findings provide a promising therapeutic strategy to modulate the immunosuppressive microenvironment of pancreatic ductal adenocarcinoma with severe perineural invasion.
Min-Wei Yang, Ling-ye Tao, Yong-sheng Jiang, JianYu Yang, Y. Huo, De-Jun Liu, Jiao Li, Xueliang Fu, Rui-zhe He, Chaoyi Lin, Wei Liu, Jun-Feng Zhang, R. Hua, Qing Li, Shuheng Jiang, Lipeng Hu, Guangang Tian, Xiao-Xin Zhang, Ningning Niu, P. Lu, Juanjuan Shi, G. Xiao, Li-wei Wang, J. Xue, Zhi-gang Zhang, Yong-wei Sun   +25 more
semanticscholar   +1 more source

Pancreatic Ductal Adenocarcinoma and Its Variants: Pearls and Perils.

Radiographics, 2020
Pancreatic ductal adenocarcinoma (PDAC), an epithelial neoplasm derived from the pancreatic ductal tree, is the most common histologic type of pancreatic cancer and accounts for 85%-95% of all solid pancreatic tumors. As a highly lethal malignancy, it is
K. Schawkat, Maria A Manning, J. Glickman, K. Mortelé   +3 more
semanticscholar   +1 more source

Pancreatic Resection for M1 Pancreatic Ductal Adenocarcinoma

Annals of Surgical Oncology, 2006
Improved safety of pancreatic surgery has led to consideration of more aggressive approaches, such as resection for primary pancreatic ductal adenocarcinoma (PDAC) with metastatic disease (M1).A total of 29 patients who underwent pancreatic resection with resection of associated metastatic disease (interaortocaval lymph node dissection, liver resection,
Shailesh V, Shrikhande, Jörg, Kleeff, Carolin, Reiser, Jürgen, Weitz, Ulf, Hinz, Irene, Esposito, Jan, Schmidt, Helmut, Friess, Markus W, Büchler   +8 more
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Pancreatic Ductal Adenocarcinoma Derived From IPMN and Pancreatic Ductal Adenocarcinoma Concomitant With IPMN

Pancreas, 2011
Pancreatic ductal adenocarcinoma (PDAC) may derive from an intraductal papillary mucinous neoplasm (IPMN) of the pancreas or may develop in the pancreatic duct apart from IPMN. The purpose of this study was to define the clinicopathological features of these 2 entities and compare them with those of ordinary PDAC.Of 765 patients who had surgical ...
Koji, Yamaguchi, Shuichi, Kanemitsu, Takashi, Hatori, Hiroyuki, Maguchi, Yasuhiro, Shimizu, Minoru, Tada, Toshio, Nakagohri, Keiji, Hanada, Manabu, Osanai, Yutaka, Noda, Akihiko, Nakaizumi, Toru, Furukawa, Shinichi, Ban, Bunsei, Nobukawa, Yo, Kato, Masao, Tanaka   +15 more
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BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma

Nature Cell Biology, 2020
Jin-Tao Li, M. Yin, Di Wang, Jian Wang, Ming-Zhu Lei, Ye Zhang, Y. Liu, Lei Zhang, Shao-wu Zou, Lipeng Hu, Zhi-gang Zhang, Yi-Ping Wang, Wenyan Wen, Hao-Jie Lu, Zhengju Chen, Dan Su, Q. Lei   +16 more
semanticscholar   +1 more source