Results 261 to 270 of about 439,784 (298)

Structure of native porcine pancreatic elastase at 1.65 A resolutions.

Acta Crystallographica Section B Structural Science, 1988
The structure of native porcine pancreatic elastase in 70% methanol has been refined using film data to 1.65 A resolution, R = 0.169. A total of 134 molecules of water (but no methanol) has been refined.
E. Meyer, G. Cole, R. Radhakrishnan, O. Epp   +3 more
semanticscholar   +1 more source

Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors.

Biochemistry, 1989
The serine protease family of enzymes is one of the most widely studied group of enzymes, as evidenced by the fact that more crystal structures are available for individuals of this superfamily than for any other homologous group of enzymes.
W. Bode, E. Meyer, J. Powers
semanticscholar   +1 more source

Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G.

Journal of Medicinal Chemistry, 1990
Comparison of MeO-Suc-Val-Pro-Phe-CO2Me (29) and MeO-Suc-Ala-Ala-Pro-Phe- CO2Me (25) with their corresponding trifluoromethyl ketones 9a and 9b, respectively, in rat and human neutrophil cathepsin G assays showed the alpha-keto esters to be more potent ...
N. Peet, J. P. Burkhart, M. Angelastro, E. Giroux, S. Mehdi, P. Bey, M. Kolb, B. Neises, D. Schirlin   +8 more
semanticscholar   +1 more source

Comparison of the Elastolytic Effects of Human Leukocyte Elastase and Porcine Pancreatic Elastase

Biochemical and Biophysical Research Communications, 1976
Porcine and bovine elastins were digested by human leukocyte elastase and porcine pancreatic elastase. The enzymes showed similarities in the extent to which they digested elastin and the pattern and quantitative distribution of N-terminal amino acids in the digests.
Robert M. Senior, Barry C. Starcher, David R. Bielefeld   +2 more
openaire   +5 more sources

The effect of pancreatic elastase on diabetic nephropathy

Diabetes Research and Clinical Practice, 1994
Pancreatic elastase has been shown to inhibit the thickening of glomerular basement membranes in experimental diabetic animals. We explored the clinical significance of the prolonged administration of pancreatic elastase on diabetic nephropathy, in patients whose blood glucose levels and blood pressure were controlled.
openaire   +3 more sources

Urinary Elastase 1 in Chronic Pancreatic Disease

Enzyme, 1989
Serum and urine elastase 1, its renal output and clearance and urinary gamma-glutamyltransferase and ribonuclease excretions were measured in 16 patients with pancreatic cancer, 23 with chronic pancreatitis and in 22 healthy controls in order to evaluate elastase 1 plasma-urine transfer in chronic pancreatic disease and to investigate any factors that ...
C. Fabris, D. Basso, L. Benini, T. Meggiato, G. Del Favero, G. Cavallini, M.P. Panozzo, P. Fogar, C. Angonese, I. Vantini, A. Piccoli, M. Plebani, R. Naccarato   +12 more
openaire   +4 more sources

Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas.

DNA, 1987
The primary structures of porcine and human pancreatic elastase II precursors were elucidated by molecular cloning and cDNA sequence analysis. The sequences of the cDNAs cloned from a human pancreatic cDNA library indicate that at least two elastases II ...
I. Kawashima, T. Tani, K. Shimoda, Y. Takiguchi   +3 more
semanticscholar   +1 more source

Elastase 1 in Acute Pancreatitis

1987
Besides the introduction of new imaging techniques, the diagnostics of acute pancreatitis have been improved in the last 10 years by new methods of specific pancreatic enzyme determination in serum [3, 7, 8, 11, 18]. Elastase of the pancreas seems to play a dominant role in the pathogenesis of acute pancreatitis, since this proteolytic and elastolytic ...
Peter Malfertheiner, W. Uhl, Markus W. Büchler   +2 more
openaire   +2 more sources

Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II. Bovine chymotrypsin A alpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates.

Biochemistry, 1984
The primary subsite specificities of human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II, bovine chymotrypsin A alpha, and the protease from strain V-8 of Staphylococcus aureus have been mapped with a ...
Harper Jw, Cook Rr, Roberts Cj, McLaughlin Bj, James C. Powers   +4 more
semanticscholar   +1 more source

Isolation and characterization of rat pancreatic elastase

Biochemistry, 1983
Proelastase has been purified to homogeneity from rat pancreatic tissue by a combination of CM-Sephadex and immobilized protease inhibitor affinity resins. Trypsin activation yields an elastolytic enzyme that possesses a specificity toward small hydrophobic residues in synthetic amide substrates, similar to those of porcine elastase 1 and canine ...
openaire   +3 more sources