Results 41 to 50 of about 222,245 (297)

Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model. [PDF]

, 2012
Pancreatic duct glands (PDGs) have been hypothesized to give rise to pancreatic intraepithelial neoplasia (PanIN). Treatment with the glucagon-like peptide (GLP)-1 analog, exendin-4, for 12 weeks induced the expansion of PDGs with mucinous metaplasia and
Butler, Peter C, Dawson, David, Dry, Sarah M, Gier, Belinda, Kirakossian, David, Matveyenko, Aleksey V   +5 more
core   +1 more source

Features of thromboelastogram in populations exposed to or transferring from high altitude

Heliyon
Background: Thromboelastogram (TEG) is an effective indicator that monitors the dynamic changes of blood coagulation in real-time. It still remains controversial about the performance and influence of coagulation at high altitude.
Zhu Huang, Dong-xin Huang, Yan-yan Wang, Li-juan Jiang, Yong-hua Wang, Jing Dai, Xia Kang, Yi Wen, Si-yi He   +8 more
doaj   +1 more source

Pancreas-preserving double pancreaticogastrostomy after traumatic injury to the head of the pancreas: a case report

Journal of International Medical Research, 2020
Traumatic injury to the main pancreatic duct requires surgical treatment, but optimal management strategies have not been established. In patients with isolated pancreatic injury, the pancreatic parenchyma must be preserved to maintain long-term quality ...
Yuichi Aoki, Hideki Sasanuma, Yuki Kimura, Akira Saito, Kazue Morishima, Yuji Kaneda, Kazuhiro Endo, Atsushi Yoshida, Atsushi Kihara, Yasunaru Sakuma, Hisanaga Horie, Yoshinori Hosoya, Alan Kawarai Lefor, Naohiro Sata   +13 more
doaj   +1 more source

An overview of pancreatic trauma

Journal of Pancreatology, 2020
. Pancreatic trauma remains a challenge to a trauma surgeon even with extensive advancement in medicine. The mortality and morbidity associated with this injury remain high.
Harshit Agarwal, MS, MCh, Amit Gupta, MS, FRCS, Subodh Kumar, MS, FRCS   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Time course of lung injury in rat acute pancreatitis [PDF]

, 2018
Objective: Lung injury is asevere complication of acute pancreatitis that increases the mortality rate of the disease. The pathophysiology of acute pancreatitis has been studied in several experimental models, but the kinetics of pulmonary complications ...
Cikirikcioglu, Banu, Frossard, Jean-Louis, Morel, Denis, Pastor, Catherine, Tapponnier, Maxime   +4 more
core  

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

miRNA-125b-5p-rich exosomes derived from fibro-adipogenic progenitors promoting muscle regeneration through inducing pro-regenerative macrophages

Stem Cell Research & Therapy
It is still unclear the role of exosomes derived from fibro-adipogenic progenitors (FAP) on macrophage polarization and muscle repair. In this study, the effects of exosomes collected from primary FAPs isolated from acute injured muscles at different ...
Meng-meng Yang, Jing-ya Luo, Jia Cai, Jin Qian, Xiao-yan Zhu, Hui-zhen Zou, Gao-ming Li, Jing Dai, Huang Zhu, Wei Li, Li-dan Zhang, Xia Kang   +11 more
doaj   +1 more source

Traumatic Pancreatic Injury Presentation, Management, and Outcome: An Observational Retrospective Study From a Level 1 Trauma Center

Frontiers in Surgery, 2022
BackgroundWe aimed to study the presentation, management, and outcomes of patients with a pancreatic traumatic injury.MethodsWe retrospectively analyzed data for all patients who were admitted with pancreatic injuries between 2011 and 2017 at the only ...
Hassan Al-Thani, Ahmed Faidh Ramzee, Ammar Al-Hassani, Gustav Strandvik, Ayman El-Menyar, Ayman El-Menyar   +5 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source