Results 31 to 40 of about 836,777 (260)

The novel mTOR inhibitor RAD001 (Everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells [PDF]

, 2007
Background/Aim: Tumors exhibiting constitutively activated PI(3) K/Akt/mTOR signaling are hypersensitive to mTOR inhibitors such as RAD001 (everolimus) which is presently being investigated in clinical phase II trials in various tumor entities, including
Brand, Stephan, Göke, Burkhard, Spoettl, Gerald, De Toni, Enrico N., Meyer, Heinrich H. D., Meinecke, Jennifer, Zitzmann, Kathrin, Auernhammer, Christoph J., Zitzmann, Kathrin;De Toni, Enrico N.;Brand, Stephan;Göke, Burkhard;Meinecke, Jennifer;Spöttl, Gerald;Meyer, Heinrich H.D.;Auernhammer, Christoph J.   +8 more
core   +1 more source

Non functional pancreatic neuroendocrine tumors

, 2021
Nonfunctioning Pancreatic Neuroendocrine Neoplasia (NF-PanNEN) are a wide group of heterogeneous tumors, increasingly diagnosed in recent years. NF-PanNEN are classified in different categories based on Ki67 proliferation index and their morphology (well
Muffatti F., Partelli S., Andreasi V., Falconi M.   +3 more
core   +1 more source

Characterization of the neuroendocrine pancreatic tumors nature by MDCT enhancement pattern: a radio-pathological correlation [PDF]

, 2012
Introduction Pre-operative suspicion of neuroendocrine pancreatic lesions nature arises both from clinical (presence and the type of secreted hormone) and imaging findings.
NOVARIA, LISA
core   +1 more source

Expression of a neuroendocrine gene signature in gastric tumor cells from CEA 424-SV40 large T antigen-transgenic mice depends on SV40 large T antigen. [PDF]

, 2012
A large fraction of murine tumors induced by transgenic expression of SV40 large T antigen (SV40 TAg) exhibits a neuroendocrine phenotype. It is unclear whether SV40 TAg induces the neuroendocrine phenotype by preferential transformation of progenitor ...
Georg Enders (187983), Vetter Elena Viviana, Schultze, Joachim L., Elena Viviana Vetter (187975), Wolfgang Zimmermann, Elena Viviana Vetter, Pan Jie, Joachim L. Schultze, Zimmermann Wolfgang, Ihler, Fritz, Jie Pan, Joachim L Schultze, Debey-Pascher Svenja, Schultze Joachim L., Enders, Georg, Pan, Jie, Kammerer Robert, Zimmermann, Wolfgang, Svenja Debey-Pascher (187980), Wolfgang Zimmermann (1543), Vetter, Elena Viviana, Georg Enders, Robert Kammerer, Kammerer, Robert, Robert Kammerer (72621), Enders Georg, Ihler Fritz, Joachim L. Schultze (133356), Debey-Pascher, Svenja, Jie Pan (187977), Fritz Ihler (187972), Fritz Ihler, Svenja Debey-Pascher   +32 more
core   +1 more source

Everolimus for Advanced Pancreatic Neuroendocrine Tumors [PDF]

New England Journal of Medicine, 2011
Everolimus, an oral inhibitor of mammalian target of rapamycin (mTOR), has shown antitumor activity in patients with advanced pancreatic neuroendocrine tumors, in two phase 2 studies. We evaluated the agent in a prospective, randomized, phase 3 study.We randomly assigned 410 patients who had advanced, low-grade or intermediate-grade pancreatic ...
Yao J.C., Shah M.H., Ito T., Bohas C.L., Wolin E.M., Van Cutsem E., Hobday T.J., Okusaka T., Capdevila J., de Vries E.G., TOMASSETTI, PAOLA, Pavel M.E., Hoosen S., Haas T., Lincy J., Lebwohl D., Öberg K.   +16 more
openaire   +3 more sources

When pancreas solid mass meets liver cystic lesion: A case report

Journal of Pancreatology, 2021
. Pancreatic neuroendocrine tumors are in low incidence compared with other pancreatic tumors, and they present as various pathological forms, including solid, cystic and solid-cystic lesions. Herein, we report a rare case that presents cystic lesions in
Haifeng Han, Jian Yang, Sanyuan Hu, Hanxiang Zhan   +3 more
doaj   +1 more source

Prognosis after surgery for multiple endocrine neoplasia type 1-related pancreatic neuroendocrine tumors: Functionality matters [PDF]

, 2020
Background: Metastasized pancreatic neuroendocrine tumors are the leading cause of death in patients with multiple endocrine neoplasia type 1. Aside from tumor size, prognostic factors of pancreatic neuroendocrine tumors are largely unknown.
Goudet, P. (Pierre), Nilubol, N. (Naris), Brandi, M.L., Brunaud, L. (Laurent), Kazemier, G. (Geert), Goor, H. (Harry) van, Conemans, E.B. (Elfi B.), Valk, G.D. (Gerlof), Giusti, F. (Francesca), Eijck, C.H.J. (Casper) van, Hsiao, R. (Ralph), Pasternak, J.D. (Jesse D.), Giri, S. (Sneha), Brosens, L.A. (Lodewijk), Vriens, M.R. (Menno), Bonsing, B.A. (Bert), Dejong, C.H. (Cees), Verkooijen, H.M. (Helena M.), Santucci, N. (Nicolas), Zagzag, J. (Jonathan), Borel Rinkes, I.H.M. (Inne), Manoharan, J. (Jerena), Nieveen Van Dijkum, E.J.M. (Els), Nell, S. (Sjoerd), Kleine, R.H.J. (Ruben) de, Sturgeon, C. (Cord), Bartsch, D.K. (Detlef), van Beek, D.-J. (Dirk-Jan), Perrier, N.D. (Nancy D.)   +28 more
core   +5 more sources

ATP6AP2 is robustly expressed in pancreatic β cells and neuroendocrine tumors, and plays a role in maintaining cellular viability

Scientific Reports, 2023
ATP6AP2, also known as (pro)renin receptor, has been shown to be expressed in several tissues including pancreatic β cells. Whereas ATP6AP2 plays an important role in regulating insulin secretion in mouse pancreatic β cells, the expression profiles and ...
Tomomi Taguchi, Kaori Kimura, Agena Suzuki, Rei Fujishima, Naoya Shimizu, Ayako Hoshiyama, Tsuguto Masaki, Mitsuko Inoue, Yukiko Kato, Takebe Satomi, Koji Takano, Tasuku Imada, Shugo Sasaki, Takeshi Miyatsuka   +13 more
doaj   +1 more source

Carcinoid Syndrome and Hyperinsulinemic Hypoglycemia Associated with Neuroendocrine Neoplasms: A Critical Review on Clinical and Pharmacological Management

Pharmaceuticals, 2021
The carcinoid syndrome (CS) and hyperinsulinemic hypoglycemia (HH) represent two of the most common clinical syndromes associated with neuroendocrine neoplasms (NENs).
Francesca Spada, Roberta E. Rossi, Elda Kara, Alice Laffi, Sara Massironi, Manila Rubino, Franco Grimaldi, Sherrie Bhoori, Nicola Fazio   +8 more
doaj   +1 more source

Peptide receptor radionuclide therapy controls inappropriate calcitriol secretion in a pancreatic neuro-endocrine tumor: a case report

BMC Gastroenterology, 2020
Background Hypercalcemia of malignancy is not uncommon in patients with advanced stage cancer. In rare cases the cause of the hypercalcemia is excessive production of calcitriol, the active form of vitamin D.
Maarten Haemels, Thierry Delaunoit, Koen Van Laere, Eric Van Cutsem, Chris Verslype, Christophe M. Deroose   +5 more
doaj   +1 more source