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Hesperidin Alleviates Acute Necrotizing Pancreatitis by Activating SIRT1 ‒ Molecular Docking, Molecular Dynamics Simulation, and Experimental Validation.

Combinatorial chemistry & high throughput screening, 2023
BACKGROUND Acute necrotizing pancreatitis is a serious pancreatic injury with limited effective treatments. This study aims to investigate the therapeutic effects of hesperidin on L-arginine-induced acute pancreatitis and its potential targets ...
Rui Zhang   +7 more
semanticscholar   +1 more source

Prognostic factors associated with development of infected necrosis in patients with acute necrotizing or severe pancreatitis—A systematic review and meta-analysis

Journal of Trauma and Acute Care Surgery, 2021
This meta-analysis confirms the association between several clinical early prognostic factors and the risk of IPN development among patients with severe or necrotizing pancreatitis.
Alexandre Tran   +10 more
semanticscholar   +1 more source

Risk of Venous Thromboembolism in Acute Necrotizing Pancreatitis

Pancreas, 2021
Supplemental digital content is available in the text. Objectives Studies on the incidence of venous thromboembolism (VTE) in acute pancreatitis (AP) are scarce. We conducted a large database study to evaluate this relationship.
D. Ahmad   +6 more
semanticscholar   +1 more source

Acute necrotizing pancreatitis

The American Journal of Digestive Diseases, 1974
A simple, easily reproducible model of experimental pancreatitis is presented. By means of a catheter implanted in the pancreas, interstitial injections were performed in order to produce acute pancreatitis in guinea pigs. Injection of a sodium taurocholate solution with 50 mg/ml cephalothin produced lethal necrotizing pancreatitis similar to that ...
J B, Bawnik, R, Orda, T, Wiznitzer
openaire   +2 more sources

Severe Acute Pancreatitis and Necrotizing Pancreatitis

Critical Care Clinics, 2016
Acute pancreatitis results in nearly 250,000 admissions annually. Acute pancreatitis varies widely in its clinical presentation. Pancreatic necrosis accounts for substantial additional morbidity, with mortality rates remaining as high as 10% to 20% despite advances in critical care.
Rahul, Maheshwari, Ram M, Subramanian
openaire   +2 more sources

Efficacy and Safety of Early Systemic Anticoagulation for Preventing Splanchnic Thrombosis in Acute Necrotizing Pancreatitis

Pancreas, 2020
Objectives Splanchnic venous thrombosis (SVT) is a relevant complication in patients with acute necrotizing pancreatitis. So far, no specific treatment for preventing development of SVT exists, and the effect of systemic anticoagulation (SAC) is unclear.
Jing Zhou   +10 more
semanticscholar   +1 more source

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