Results 21 to 30 of about 274,531 (173)

2DE- based proteomics for the analysis of metastasis associated proteins [PDF]

, 2012
Two-dimensional electrophoresis (2-DE) is a high-resolution technique for analysis and comparison of complex protein mixtures. With the advent of recent technical developments, its application has become significant in a wide range of fields.
Dwek, M., Peiris, D.
core   +1 more source

Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis [PDF]

, 2015
BACKGROUND & AIMS: The pathogenic mechanism of pancreatitis is poorly understood. Recent evidence implicates defective autophagy in pancreatitis responses; however, the pathways mediating impaired autophagy in pancreas remain largely unknown.
Yakubov, Iskandar, Gukovskaya, Anna S., French, Samuel W., Samuel W. French, Lüllmann-Rauch, Renate, Gukovskaya, Anna S, Tokhtaeva, Elmira, Gukovsky, Ilya, Ilya Gukovsky, Oorschot, Viola, Mareninova, Olga A., Iskandar Yakubov, Renate Lüllmann-Rauch, Lerch, Markus M, Mayerle, Julia, Julia Mayerle, Vagin, Olga, Klumperman, Judith, Sendler, Matthias, Elmira Tokhtaeva, Viola Oorschot, Judith Blanz, Olga A. Mareninova, French, Samuel W, Sudarshan Ravi Malla, Markus M. Lerch, Malla, Sudarshan Ravi, Blanz, Judith, Matthias Sendler, Anna S. Gukovskaya, Dawson, David, Olga Vagin, Mareninova, Olga A, Lerch, Markus M., Judith Klumperman, David Dawson   +35 more
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Studies on interactions of exported "plasmodium falciparum" membrane proteins [PDF]

, 2014
Responsible for about 700’000 annual deaths worldwide, malaria today is still one of the major health problems in developing countries. The most deadly form of human malaria called malaria tropica is caused by the apicomplexan parasite Plasmodium ...
Dietz, Olivier
core   +1 more source

Proteomics portrait of archival lesions of chronic pancreatitis. [PDF]

, 2011
Chronic pancreatitis is a chronic inflammatory disorder of the pancreas. The etiology is multi-fold, but all lead to progressive scarring and loss of pancreatic function.
Ru Chen, Stevens Tyler, Martin W. McIntosh, Teresa A. Brentnall, Mary P. Bronner, Sheng Pan, Tyler Stevens, Mary P Bronner, Martin W McIntosh, Chen Ru, Teresa A Brentnall, Brentnall Teresa A., Bronner Mary P., May Damon, Tamura Yasuko, McIntosh Martin W., Yasuko Tamura, Pan Sheng, Damon May   +18 more
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Crenarchaeal chromatin proteins Cren7 and Sul7 compact DNA by inducing rigid bends [PDF]

, 2012
Archaeal chromatin proteins share molecular and functional similarities with both bacterial and eukaryotic chromatin proteins. These proteins play an important role in functionally organizing the genomic DNA into a compact nucleoid.
White, Malcolm F., Meng, He, van Noort, John, Noort, S.J.T. van, Schiessel, Helmut, Shahapure, Rajesh, Lanzani, G., Meng, H., Dame, Remus Th, Driessen, R.P.C., Shahapure, R., Suresh, G., Driessen, Rosalie P. C., Lanzani, Giovanni, Suresh, Gorle, Schiessel, H., Dame, R.T., Priyakumar, U. Deva, Priyakumar, U.D., White, M.F.   +19 more
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Identification of a novel zinc metalloprotease through a global analysis of clostridium difficile extracellular proteins [PDF]

, 2013
Clostridium difficile is a major cause of infectious diarrhea worldwide. Although the cell surface proteins are recognized to be important in clostridial pathogenesis, biological functions of only a few are known.
Maria Scarselli (247406), Norais Nathalie, Jeffrey T. Rubino (490079), Norais, Nathalie, Leuzzi, Rosanna, Massimiliano Biagini, Biagini Massimiliano, Martinelli Manuele, Scarselli, Maria, Jeffrey T Rubino, Serruto Davide, Manuele Martinelli, Rosanna Leuzzi (490078), Nathalie Norais, Davide Serruto, Rosanna Leuzzi, Rubino, Jeffrey T., Nathalie Norais (159651), Serruto, Davide, Unnikrishnan, Meera, Manuele Martinelli (272421), Cantini Francesca, Francesca Cantini, Maria Scarselli, Martinelli, Manuele, Cantini, Francesca, Biagini, Massimiliano, Meera Unnikrishnan, Rubino Jeffrey T., Valeria Cafardi (490077), Massimiliano Biagini (247421), Unnikrishnan Meera, Cafardi, Valeria, Leuzzi Rosanna, Cafardi Valeria, Valeria Cafardi, Meera Unnikrishnan (183268), Scarselli Maria, Francesca Cantini (208272), Davide Serruto (148434)   +39 more
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Ubiquitin-specific protease USP25 functions in endoplasmic reticulum-associated degradation [PDF]

, 2012
Endoplasmic Reticulum (ER)-associated degradation (ERAD) discards abnormal proteins synthesized in the ER. Through coordinated actions of ERAD components, misfolded/anomalous proteins are recognized, ubiquitinated, extracted from the ER and ultimately ...
Amanda Denuc, Marfany Gemma, Denuc Isern, Amanda, Todi, S. V., Burr, A. A., Gemma Marfany, Blount Jessica R., Sokol V Todi, Todi Sokol V., Marfany i Nadal, Gemma, Jessica R Blount, Denuc Amanda, Blount, J. R., Aaron A Burr, Burr Aaron A.   +14 more
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Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins [PDF]

, 2014
An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. A fundamental question is whether toxicity is driven by the repeat RNA itself and/or by dipeptide repeat proteins ...
Ridler, CE, Pickering-Brown, Stuart, Norona, FE, Woollacott, I., Fratta, P., Norona, Frances E, Woollacott, IOC, Ridler, Charlotte E, Devoy, A, Pietrzyk, J, Fisher, EMC, Devoy, Anny, Dols, J, Dols, Jacqueline, Moens, T., Cleverley, K., Fratta, Pietro, Partridge, Linda, Nicoll, Andrew J, Fisher, E., Ridler, C., Fratta, P, Grönke, S., Pickering-Brown, S., Isaacs, Adrian M, Cabecinha, Melissa, Mizielinska, S, Moens, Thomas, Clayton, E., Partridge, L., Pietrzyk, J., Clayton, Emma L, Mizielinska, Sarah, Niccoli, T., Devoy, Anny; id_orcid, Mizielinska, Sarah; id_orcid, Isaacs, A., Woollacott, Ione O C, Cleverley, Karen, Nicoll, AJ, Hendrich, O., Moens, T, Dols, J., Grönke, Sebastian, Cabecinha, M., Cabecinha, M, Fisher, Elizabeth M C, Mizielinska, S., Clayton, EL, Nicoll, A., Hendrich, Oliver, Grönke, S, Niccoli, Teresa, Pietrzyk, Julian, Devoy, A., Norona, F., Isaacs, AM, Pickering-Brown, S, Cleverley, K, Hendrich, O, Niccoli, T, Partridge, L   +61 more
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An Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking

Advanced Science, EarlyView.
This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang, Guangbing Duan, Huihui Sun, Zhiyu Dong, Qiwei Wang, Xiaowei Li, Ying Chen, Shuchang Xu, Ying Huang   +8 more
wiley   +1 more source