Results 31 to 40 of about 5,405 (217)

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation [PDF]

, 2010
A major obstacle for the discovery of psychoactive drugs is the inability to predict how small molecules will alter complex behaviors. We report the development and application of a high-throughput, quantitative screen for drugs that alter the behavior ...
Arvanites, Anthony, Haggarty, Stephen J., Jang, Sumin, Kokel, David, Lam, Kelvin, Peterson, Randall T., Prober, David A., Rihel, Jason, Rubin, Lee L., Schier, Alexander F., Zimmerman, Steven   +10 more
core   +1 more source

Brain‐Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety‐Like Behaviors in Mice

Advanced Science, Volume 12, Issue 40, October 27, 2025.
J.Liu et al. reveal the complete propagation dynamics of cortical traveling waves, from local circuitry initiation to long‐range propagation, and identify their functional relevance in modulating anxiety‐like behaviors and underlying cellular neuroplasticity in mice.
Jiaming Liu, Jia‐Wen Mo, Xunda Wang, Yinuo Ma, Shile Tian, Qi Wang, Peng‐Li Kong, Ziqi An, Li Ding, Jing Ren, Cheng‐Lin Lu, Chuanjun Tong, Ed X. Wu, Qiu‐gen Hu, Xiong Cao, Yanqiu Feng   +15 more
wiley   +1 more source

Death Bed [PDF]

, 2006
Lethal injection is this country\u27s primary method of execution, adopted for use by all but one of the thirty-seven death penalty states, as well as the federal government.
Denno, Deborah W.
core   +1 more source

Methacholine hyperresponsiveness in mice with house dust mite‐induced lung inflammation is not associated with excessive airway constriction ex vivo

Experimental Physiology, Volume 110, Issue 9, Page 1336-1348, September 1, 2025.
Abstract The role of excessive airway constriction in the hyperresponsiveness to nebulized methacholine in mice with experimental asthma is still contentious. Yet, there have been very few studies investigating whether the increased in vivo response to methacholine caused by experimental asthma is associated with a corresponding increase in ex vivo ...
Andrés Rojas‐Ruiz, Magali Boucher, Cyndi Henry, Louis Gélinas, Rosalie Packwood, Percival Graham, Jorge Soliz, Ynuk Bossé   +7 more
wiley   +1 more source

Inhibition and potentiation of the exercise pressor reflex by pharmacological modulation of TRPC6 in male rats

The Journal of Physiology, Volume 603, Issue 18, Page 5027-5052, September 15, 2025.
Abstract figure legend The majority of L4–L5 dorsal root ganglion cells innervating the triceps surae muscles of healthy rats expressed TRPC6 channels. In decerebrated rats, pharmacological inhibition of TRPC6 channels by injection of antagonists (SAR7334 or BI‐749327) into the arterial supply of the triceps surae muscles inhibited the exercise pressor
Guillaume P. Ducrocq, Laura Anselmi, Salvatore L. Stella Jr, Steven W. Copp, Victor Ruiz‐Velasco, Marc P. Kaufman   +5 more
wiley   +1 more source

Lactate and hydrogen ions play a predominant role in evoking the exercise pressor reflex during ischaemic contractions but not during freely perfused contractions

The Journal of Physiology, Volume 603, Issue 18, Page 5053-5070, September 15, 2025.
Abstract figure legend The role of lactate and hydrogen ions in evoking the metabolic component of the exercise pressor reflex was studied in rats with either a functional pygm gene (pygm+/+) or with a non‐functional “knocked out” pygm gene (pygm−/−). The pygm gene is responsible for producing the myophosphorylase enzyme which catalyses the breakdown ...
Guillaume P. Ducrocq, Laura Anselmi, Victor Ruiz‐Velasco, Marc P. Kaufman   +3 more
wiley   +1 more source

The effect of open lung ventilation on right ventricular and left ventricular function in lung-lavaged pigs [PDF]

, 2006
INTRODUCTION: Ventilation according to the open lung concept (OLC) consists of recruitment maneuvers, followed by low tidal volume and high positive end-expiratory pressure, aiming at minimizing atelectasis.
Bogers, A.J.J.C. (Ad), Cademartiri, F. (Filippo), Gommers, D.A.M.P.J. (Diederik), Haitsma, J.J. (Jack), Klompe, L. (Lennart), Lachmann, B.F. (Burkhard), Palumbo, A. (Alessandro), Reis Miranda, D. (Dinis) dos, Takkenberg, J.J.M. (Hanneke)   +8 more
core   +2 more sources

De Novo Variant in GBX1 Gene Associated With Developmental Delay and Focal Epilepsy

Molecular Genetics &Genomic Medicine, Volume 13, Issue 6, June 2025.
We first identified an association between the GBX1 gene variant and focal epilepsy, and observed related phenotypes in the gbx1‐Cas9 zebrafish model. ABSTRACT Background The gastrulation brain homeobox (Gbx) family, including GBX1 and GBX2, is crucial for hindbrain development and contributes to the morphogenesis of the midbrain–hindbrain boundary ...
Bingbing Zhang, Xiaohua Li, Xiao Qian, Jihong Tang   +3 more
wiley   +1 more source

PRMT1 Ablation in Endothelial Cells Causes Endothelial Dysfunction and Aggravates COPD Attributable to Dysregulated NF‐κB Signaling

Advanced Science, Volume 12, Issue 19, May 22, 2025.
This study investigates the role of protein arginine methyltransferase 1 (PRMT1) in endothelial cells (ECs) in chronic obstructive pulmonary disease (COPD). Mice with endothelial‐specific PRMT1 deletion develop pulmonary hemorrhage, inflammation, and apoptosis, driven by excessive nuclear factor kappa B activation.
Thi Thuy Vy Tran, Yideul Jeong, Suwoo Kim, Ji Eun Yeom, Jinwoo Lee, Wonhwa Lee, Gyu‐Un Bae, Jong‐Sun Kang   +7 more
wiley   +1 more source

Leukocyte margination in alveolar capillaries: Interrelationship with functional capillary geometry and microhemodynamics [PDF]

, 1999
The pulmonary capillary microvasculature harbors a large pool of intravascularly marginated leukocytes. In this study, we investigated the interrelationship of leukocyte margination with characteristics of functional capillary geometry and ...
Goetz, Alwin Eduard, Kuebler, Wolfgang M., Kuhnle, Gerhard E. H.   +2 more
core   +1 more source