Results 41 to 50 of about 5,405 (217)

d‐Amphetamine and Feeding States Cohesively Affect Locomotion and Motor Neuron Response in Zebrafish Larvae

Brain and Behavior, Volume 14, Issue 12, December 2024.
This preclinical explores the concomitant effect of different feeding states and amphetamine on behavior and brain using larval zebrafish as an animal model. Here, the zebrafish larvae were kept in satiated and food‐deprived state acutely and chronically followed by an acute amphetamine treatment.
Pushkar Bansal, Mitchell F. Roitman, Erica E. Jung   +2 more
wiley   +1 more source

Modulation of Hypothalamic Dopamine Neuron Activity by Interaction Between Caloric State and Amphetamine in Zebrafish Larvae

Journal of Neuroscience Research, Volume 102, Issue 11, November 2024.
ABSTRACT Dopamine (DA) signaling is evoked by both food and drugs that humans come to abuse. Moreover, physiological state (e.g., hunger versus satiety) can modulate the response. However, there is great heterogeneity among DA neurons. Limited studies have been performed that could resolve the interaction between physiological state and drug ...
Pushkar Bansal, Mitchell F. Roitman, Erica E. Jung   +2 more
wiley   +1 more source

Safety and efficacy of xenon in routine use as an inhalational anaesthetic [PDF]

, 1990
40 patients (24 male, 16 female, aged 21-59 years) of American Society of Anesthesiologists class I or II who were undergoing routine surgery took part in a randomised, double-blind comparison of the anaesthetic efficacy and potency of xenon and nitrous ...
Armbruster, S. (S.), Daal, G.J. (Geert-Jan) van, Erdmann, W. (Wilhelm), Kusuma, A. (Ari), Lachmann, B.F. (Burkhard), Landstra, A.M. (A. M.), Schairer, W. (W.), Trouwborst, A. (Adrianus)   +7 more
core   +1 more source

The protein disulfide isomerase A3 and osteopontin axis promotes influenza‐induced lung remodelling

British Journal of Pharmacology, Volume 181, Issue 22, Page 4610-4627, November 2024.
Abstract Background and Purpose Fibrotic lung remodelling after a respiratory viral infection represents a debilitating clinical sequela. Studying or managing viral–fibrotic sequela remains challenging, due to limited therapeutic options and lack of understanding of mechanisms.
Amit Kumar, Zoe F. Mark, Morgan P. Carbajal, Dhemerson Souza DeLima, Nicolas Chamberlain, Joseph Walzer, Mona Ruban, Ravishankar Chandrasekaran, Nirav Daphtary, Minara Aliyeva, Matthew E. Poynter, Yvonne M. W. Janssen‐Heininger, Jason H. Bates, John F. Alcorn, Clemente J. Britto, Charles S. Dela Cruz, Anil G. Jegga, Vikas Anathy   +17 more
wiley   +1 more source

The choice of the intravenous fluid influences the tolerance of acute normovolemic anemia in anesthetized domestic pigs [PDF]

, 2012
The correction of hypovolemia with acellular fluids results in acute normovolemic anemia. Whether the choice of the infusion fluid has an impact on the maintenance of oxygen (O2) supply during acute normovolemic anemia has not been investigated so far ...
Habler, Oliver, Horn, Oliver, Kertscho, Harry, Kutschker, Saskia, Lossen, Mischa, Pape, Andreas, Stein, Peter, Zwissler, Bernhard   +7 more
core   +2 more sources

Alveolar distribution of nebulized solution in health and lung injury assessed by confocal microscopy

Physiological Reports, Volume 12, Issue 20, October 2024.
Abstract Parenchymal distribution of nebulized drug in healthy and diseased lungs has not, as evident from a literature review, been well characterized. We use a vibrating mesh nebulizer to deliver fluorescein solution in vivo to healthy or intratracheal‐lipopolysaccharide (LPS)‐instilled anesthetized rats in dorsal recumbency, or ex vivo to the lungs ...
Zahra Ansari, John Battikha, Charul Singh, Carrie E. Perlman   +3 more
wiley   +1 more source

DISTRIBUTION AND KINETICS OF 14C-VECURONIUM IN RATS AND MICE [PDF]

, 2017
The distribution and kinetics of 14C-vecuronium were studied in rats and mice. 14C-Vecuronium accumulated rapidly in the liver. Both unchanged and metabolized vecuronium were excreted with the bile into the intestines and stomach. Reabsorption in the gut
KAISER-SCHÖNENBERGER, E., SIN-REN, A. CHANG, WASER, P. G., WIEDERKEHR, H.   +3 more
core  

Unimolecular Cucurbit[7]uril‐Based Indicator Displacement Assay with Dual Signal‐Readout for the Detection of Drugs

Analysis &Sensing, Volume 4, Issue 5, September 2024.
A dual readout chemosensor assay is presented that utilizes a cucurbit[7]uril (CB7)‐indicator conjugate for the optical and electrochemical detection of drugs in water. The assay works on the basis that the fluorescence and electrochemical properties of the reporter molecule change when it is engulfed by the CB7 or displaced from its cavity by an ...
Pierre Picchetti, Maria Vittoria Balli, Seth Baker, Nilima Manoj Kumar, Patrick Gruhs, Luca Prodi, Frank Biedermann   +6 more
wiley   +1 more source

Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes c-fiber nociceptors with broad action potentials and high nav1.9 expression [PDF]

, 2006
Binding to isolectin-B4 (IB4) and expression of tyrosine kinase A (trkA) (the high-affinity NGF receptor) have been used to define two different subgroups of nociceptive small dorsal root ganglion (DRG) neurons. We previously showed that only nociceptors
Berry, Carol, Djouhri, Laiche, Fang, Xin, Dr., Lawson, Sally N., McMullan, Simon, Okuse, Kenji, Waxman, Stephen G.   +6 more
core   +1 more source

Exploring the role of mechanical forces on tendon development using in vivo model: A scoping review

Developmental Dynamics, Volume 253, Issue 6, Page 550-565, June 2024.
Abstract Tendons transmit the muscle contraction forces to bones and drive joint movement throughout life. While extensive research have indicated the essentiality of mechanical forces on tendon development, a comprehensive understanding of the fundamental role of mechanical forces still needs to be impaerted. This scoping review aimed to summarize the
Yuna Usami, Hirotaka Iijima, Takanori Kokubun   +2 more
wiley   +1 more source