Results 121 to 130 of about 34,271 (248)

B‐Lymphoblastic Leukemia Presenting as Bilateral Ovarian Masses in a 20‐Year‐Old Woman

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Hematologic malignancies involving the ovaries are rare and may mimic ovarian carcinoma. We report a 20‐year‐old woman who presented with generalized body pain, bilateral ovarian masses, and abdominal adenopathy, initially suspected to have ovarian carcinoma.
Jennifer Cai, David Sin, Marian Varda, Lauren Lewis, James Yeh   +4 more
wiley   +1 more source

Myelodysplastic Syndromes‐Transformed Acute Myeloid Leukemia With Concurrent DEK::CAN Fusion Gene Positivity and WT1 Overexpression: A Case Report and Literature Review

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Myelodysplastic syndromes (MDS) are a group of clonal hematopoietic stem cell disorders with a risk of progression to acute myeloid leukemia (AML). MDS‐transformed AML (MDS‐AML) has a poor prognosis. The concurrent presence of DEK::CAN fusion gene positivity and WT1 overexpression is extremely rare and likely denotes a highly ...
Wanxiu Mao, Tengmin Zhou, Xi Xu, Sheng Luo, Songfu Jiang, Zhijie Yu   +5 more
wiley   +1 more source

Clinical Images: Collapsing auricles and airways in relapsing polychondritis with myelodysplastic syndrome

ACR Open Rheumatology, Volume 8, Issue 10, October 2026.
Yuqing Dan, Liling Zhao, Qiong Fu
wiley   +1 more source

One cycle of nelarabine given after induction is well tolerated but does not improve outcome in adults with T‐cell precursor acute lymphoblastic leukemia: Outcome data from the UKALL14 randomized‐controlled trial

HemaSphere, Volume 10, Issue 10, October 2026.
Abstract UKALL14 (NCT01085617) T‐cell arm was a phase 3, randomized‐controlled trial. Adults aged 25–65 years were randomized 1:1 at entry to receive standard of care (SOC) or SOC + nelarabine 1.5 g/m2 (Days 1, 3, and 5) to be administered following second induction. The primary end‐point was event‐free survival (EFS).
Clare J. Rowntree, Amy A. Kirkwood, Nadine Farah, Emma Lawrie, David I. Marks, Andrew K. McMillan, Tobias F. Menne, Anthony V. Moorman, Bela Patel, Pip Patrick, Paul Smith, Krisztina Z. Alapi, Lingyi Wang, Marc R. Mansour, Adele K. Fielding   +14 more
wiley   +1 more source

MEK inhibition achieves robust and durable responses in Erdheim–Chester disease

HemaSphere, Volume 10, Issue 10, October 2026.
Abstract Erdheim–Chester disease (ECD) is a rare histiocytic neoplasm characterized by heterogeneous clinical manifestations and limited evidence to guide targeted therapy. While MEK inhibitors (MEKi) are increasingly used, data on their real‐world efficacy, durability, and safety remain incomplete.
Francesco Pegoraro, Félicien Triboulet, Matthias Papo, Francesco Peyronel, Anita Argentieri, Jerome Razanamahery, Ahmed Idbaih, Polyzois Makras, Ofer Shpilberg, Oshrat Hershkovitz‐Rokah, Michael Girschikofsky, Matthew Collin, Kristian Bowles, Satyen H. Gohil, Rodothea Amerikanou, Emmanuel Ledoult, Tanguy Le Scornet, Mathilde de Menthon, Etienne Riviere, Xavier Boulu, Henry Dupuy, Achille Aouba, Stanislas Faguer, Xavier Solanich, Elena Sieni, Stéphane Barete, Chiara Bellino, Alessandro Tomelleri, Corrado Campochiaro, Lorenzo Dagna, Zahir Amoura, Jean‐François Emile, Fleur Cohen‐Aubart, Augusto Vaglio, Julien Haroche   +34 more
wiley   +1 more source

Clinical and Cytogenomic Characterization of Three Patients With Distal 1q43q44 Deletion: Twin Sisters With a de novo Deletion and a Patient With der(1)t(1;21)(q43;q22.3)mat

Journal of Clinical Laboratory Analysis, Volume 40, Issue 19, October 2026.
Distal 1q43q44 deletions lead to a consistent neurodevelopmental phenotype characterized by microcephaly, corpus callosum abnormalities, and developmental delay. Despite differences in genomic architecture, overlapping deletions affecting dosage‐sensitive genes such as AKT3, HNRNPU, and ZBTB18 define the core phenotype.
Ma. Guadalupe Domínguez‐Quezada, Horacio Rivera, Luis E. Figuera, Patricio Barros‐Núñez, José Luis Castrillo, Carlos Córdova‐Fletes, Thania Alejandra Aguayo‐Orozco   +6 more
wiley   +1 more source

Profile of HIV-Infected Hispanics with Pancytopenia

, 2015
Pancytopenia is seen in late HIV infection; it is associated with medical complications and with decreased survival. We determined the prevalence of pancytopenia at baseline in a cohort of HIV-positive Hispanics living in Puerto Rico, and compared their ...
Diana Fernández-Santos, Robert Hunter-Mellado, Eduardo Santiago-Rodríguez, Angel Mayor   +3 more
core   +1 more source

Acute Myeloid Leukaemia Driven by Rare HNRNPH1::ERG Fusion Gene in an Adult, With Distinct Transcripts Detected by RNASeq at Diagnosis and Relapse: A Case Report

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Acute myeloid leukaemia (AML) cases with rare fusion genes, such as ERG‐related fusions, constitute less than 1% of AML. They often present with a normal karyotype by conventional cytogenetics but are increasingly detected by RNA sequencing (RNAseq), although their characteristics and the utility of fusion genes as an MRD marker are poorly ...
Hannah Al‐Yousuf, Pablo Prieto, Robert Baker, Katherine Clesham, Kate Xu, Andrew Wilson, Jiexin Zheng, Rajeev Gupta, Rob Sellar, Jenny O'Nions   +9 more
wiley   +1 more source

Reversible Eltrombopag‐Associated Bone Marrow Fibrosis With Hematologic Recovery After Drug Withdrawal in ASXL1‐Mutated Hypoplastic Myelodysplastic Syndrome: A Case Report

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Hypoplastic myelodysplastic syndrome (MDS) often overlaps clinically with aplastic anemia and frequently involves clonal hematopoiesis. Thrombopoietin receptor agonists (TPO‐RAs), including eltrombopag, are increasingly used to treat cytopenias in hypoplastic marrow failure syndromes; however, their long‐term effects on clonal dynamics and ...
Kyoko Yoshihara, Ikuo Matsuda, Yasuhito Nannya, Mami Samori, Naru Tomigaki, Saki Takahashi, Chisato Ohe, Satoshi Yoshihara   +7 more
wiley   +1 more source

Atypical Presentation of UBE2T‐Related Fanconi Anemia With Immune‐Mediated Thrombocytopenia and Hematopoietic Somatic Mosaicism: A Case Report

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Fanconi anemia (FA) is a genetically heterogeneous disorder of chromosome instability leading to bone marrow failure (BMF) and other manifestations. We report a case of FA in which two atypical features initially obscured the diagnosis: the presence of T cell‐mediated thrombocytopenia, and somatic mosaicism leading to normal chromosome ...
Bridget T. Kiely, Alison A. Bertuch
wiley   +1 more source