Results 161 to 170 of about 3,672,328 (392)

Pandemic due to a pandemic?

Medicina Clínica (English Edition), 2022
openaire   +3 more sources

A Modular Vaccine Platform Against SARS‐CoV‐2 Based on Self‐Assembled Protein Nanoparticles

Advanced Science, EarlyView.
A modular BP26 nanoparticle vaccine platform incorporating the SpyTag/SpyCatcher system enables high‐density, repetitive antigen display with post‐expression flexibility. Conjugation of the SARS‐CoV‐2 RBD to BP26 nanoparticles elicits strong humoral immunity and confers protection against viral challenge in vivo.
Seojung Lee, Yejin Jang, Yujin Kim, Yumi Shin, Ji‐Joon Song, Meehyein Kim, Sangyong Jon   +6 more
wiley   +1 more source

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, EarlyView.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

BUMDes Sebagai Solusi Persiapan Stok Pangan dan Penyangga Ekonomi Nasional di Masa Pandemic Global “Covid-19”

, 2020
Abdul Karim
openalex   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Coordination and collaboration for strengthening respiratory surveillance at the national level: updates from workshop hosted by the WHO Hub for Pandemic and Epidemic Intelligence, 24–25 July 2024

BMC Proceedings
Recent public health emergencies, including the COVID-19 pandemic, MERS, and Avian Influenza outbreaks, underscore the need for effective surveillance systems for respiratory pathogens with epidemic and pandemic potential.
Raquel Medialdea Carrera, Aspen Hammond, Jijoho Mischael Michel, Hannah Lewis, Yeon Kyeng Lee, Lidia Alexandrova Ezerska, George Sie Williams, Wenqing Zhang, Philip AbdelMalik   +8 more
doaj   +1 more source

A protocol for a living mapping review of global research funding for infectious diseases with a pandemic potential – Pandemic PACT [version 2; peer review: 2 approved, 1 approved with reservations]

Wellcome Open Research
The COVID CIRCLE initiative Research Project Tracker by UKCDR and GloPID-R and associated living mapping review (LMR) showed the importance of sharing and analysing data on research at the point of funding to improve coordination during a pandemic.
Zaharat Kadri-Alabi, Shanthi Levanita, Emilia Antonio, Georgina Humphreys, Adrian Bucher, Nusrat Jabin, Rodrigo Furst, Olena Seminog, Alice Norton, Omid Rohanian, Thomas Mendy   +10 more
doaj   +1 more source

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

Advanced Science, EarlyView.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang, Tianxin Ma, Yujiao He, Qinming Li, Kailin Mai, Minying Mo, Chenyang Cao, Jiahui Li, Pei Feng, Jiaojiao Peng, Jing Sun, Weiqi Pan, Zifeng Yang, Ling Chen   +13 more
wiley   +1 more source

Barriers and drivers influencing people's behaviour towards COVID-19 public health and social measures in the Netherlands

Public Health in Practice
Background: The disease burden of COVID-19 infection, morbidity, and mortality was unevenly distributed across different population subgroups. A one-size-fits-all approach may not reach all groups.
Valérie Eijrond, Nora Bünemann, Nicky Renna, Brett Craig, Katrine Bach Habersaat, Hélène Voeten, Pearl Dykstra, Anja Schreijer   +7 more
doaj   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source