Results 191 to 200 of about 3,447,388 (399)

Homeostasis of Gut Microbiota Protects against Susceptibility to Fungal Pneumonia

Advanced Science, EarlyView.
Fungal pneumonia induces inflammation, shown by heightened IL‐6, IL‐1β, TNF‐α levels and a growth in Staphylococcus in the alveolar flora. The gut microbiota, acting through the gut‐lung axis via blood, impacts fungal pneumonia susceptibility by altering lung metabolism and inflammatory responses.
Jian Ji, Yongli Ye, Jiadi Sun, Lina Sheng, Jinyou Li, Jin Yang, Bing Wu, Yuting Wang, Xingxing Gao, Liang Luo, Jianfeng Ping, Yinzhi Zhang, Xiulan Sun   +12 more
wiley   +1 more source

Implications of Pandemic Influenza for Bioterrorism Response [PDF]

, 2000
Monica Schoch‐Spana
openalex   +1 more source

NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

Advanced Science, EarlyView.
Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen   +18 more
wiley   +1 more source

Quantification of the time-varying epidemic growth rate and of the delays between symptom onset and presenting to healthcare for the mpox epidemic in the UK in 2022

Scientific Reports
The mpox epidemic in the UK began in May 2022, with rates of new cases unexpectedly and rapidly declining during August 2022. Interpreting trends in infection requires disentangling the underlying growth rate of cases from the delay from symptom onset to
Robert Hinch, Jasmina Panovska-Griffiths, Thomas Ward, Andre Charlett, Nicholas Watkins, Christophe Fraser   +5 more
doaj   +1 more source

Understanding factors influencing the implementation and uptake of less-established adult vaccination programmes: A meta-ethnography of COVID-19 vaccination in Nigeria

Global Public Health
Before COVID-19, a few studies examined adult vaccination programmes for disease outbreaks in Nigeria. Recent studies explored vaccine uptake factors, but few examined implementation.
Abiola Ojumu, Siti Aishah Ibrahim, Anna C. Seale, Olufunke Fayehun, Paramjit Gill   +4 more
doaj   +1 more source

Experience of Pandemic Influenza A (H1N1) 2009 at Dhaka Medical College Hospital

, 1970
Quazi Tarikul Islam, Azizul Kahhar, Syed Mohammad Arif, HAM Nazmul Ahasan, Md Mahmudur Rahman Siddiqui, Md Shahriar Mahbub, Ahmedul Kabir, Khan Mohammad Arif, Golam Kibria, Narayan Chandra Saha   +9 more
openalex   +2 more sources

A Comprehensive Lateral Flow Strip Assay for On‐Site mRNA Vaccine Quality Control in Decentralized Manufacturing

Advanced Science, EarlyView.
A rapid, portable lateral flow strip assay for on‐site mRNA quality control is developed, enabling sequence‐independent analysis of 5' capping, integrity, and LNPs encapsulation efficiency. This cost‐effective method offers real‐time stability monitoring, reduced sample requirements, and comparable accuracy to standard techniques, enhancing ...
Dengwang Luo, Ziwei Zhang, Jing Guo, Jieli Zhang, Arong Huang, Qinghao Cao, Jiangnan Zheng, Yingjin Yuan, Daming Wang, Yuhong Cao   +9 more
wiley   +1 more source

Phase 0 trials/ Intra-Target-Microdosing (ITM) and the lung: a review

BMC Pulmonary Medicine
The COVID-19 pandemic has highlighted the importance of efficient drug discovery in respiratory disease. The traditional set up of clinical trials is expensive and allows for significant attrition of new drugs, many of which undergo extensive safety ...
Tom M. Quinn, Annya M. Bruce, Tal Burt, Kevin Dhaliwal   +3 more
doaj   +1 more source

Air and surface sampling for clade Ib monkeypox virus in United Kingdom hospitals, 2024 to 2025

Eurosurveillance
Air and surface sampling was performed in isolation rooms of seven patients with clade Ib mpox admitted to high consequence infectious disease centres in the United Kingdom.
Jake Dunning
doaj   +1 more source

The Swine Flu pandemic in Nepal

, 1970
Arpana Neopane
openalex   +2 more sources