Results 71 to 80 of about 2,612,900 (301)

Development and Evaluation of Compact Semi-Synthetic Promoters for Enhanced Antigen Expression in Adenoviral-Vectored Vaccines

open access: yesVaccines
Background/Objectives: The large size of commonly used regulatory elements such as the cytomegalovirus (CMV) immediate-early promoter imposes a significant burden on the already restricted payload capacity of first-generation adenoviral vectors ...
Matěj Hlaváč   +6 more
doaj   +1 more source

Pandemic Influenza: Ethics, Law, and the Public\u27s Health [PDF]

open access: yes, 2007
Highly pathogenic Influenza (HPAI) has captured the close attention of policy makers who regard pandemic influenza as a national security threat. Although the prevalence is currently very low, recent evidence that the 1918 pandemic was caused by an avian
Berkman, Benjamin E.   +1 more
core   +1 more source

High Health Care Utilization Preceding Diagnosis With Juvenile Idiopathic Arthritis

open access: yesArthritis Care &Research, EarlyView.
Objective Although early diagnosis improves long‐term outcomes, patients with juvenile idiopathic arthritis (JIA) often experience prolonged, circuitous paths to diagnosis. To inform diagnostic improvement, we sought to characterize health care utilization in the year preceding diagnosis. Methods We identified 10,021 patients with an incident diagnosis
Anna Costello   +5 more
wiley   +1 more source

Mpox stigma in the UK and implications for future outbreak control: a cross-sectional mixed methods study

open access: yesBMC Medicine
Background Stigma emerged as a prominent public health challenge in the global mpox outbreak that began in 2022, impeding outbreak control efforts and the well-being of affected individuals.
Amy Paterson   +10 more
doaj   +1 more source

The association of physical function with psychosocial patient‐reported outcomes in people with systemic lupus erythematosus

open access: yesArthritis Care &Research, Accepted Article.
Objective To evaluate how modifiable psychosocial factors and fatigue relate to physical functioning in patients with systemic lupus erythematosus (SLE). Methods In this cross‐sectional study of two demographically distinct cohorts [Approaches to Positive, Patient‐centered Experiences of Aging with Lupus (APPEAL) and California Lupus Epidemiology Study
Mrinalini Dey   +8 more
wiley   +1 more source

Stampede April 1, 2020 [PDF]

open access: yes, 2020
Students navigate the challenges, and even advantages, of distance education WMU still serving students\u27 Faculty stepping up to support transition to distance education Counseling Services helping students cope with pandemic-related anxiety, stress ...
Western Michigan University
core   +1 more source

Real‐world trends in prenatal antirheumatic drug utilization in Ontario, Canada: A cross‐sectional time‐series analysis

open access: yesArthritis Care &Research, Accepted Article.
Objectives This study aimed to describe real‐world trends in preconception and prenatal use of antirheumatic drugs among pregnant individuals with rheumatic diseases in Ontario, Canada. Methods We conducted a time‐series analysis using repeated cross‐sectional data to examine annual patterns of disease‐modifying antirheumatic drug (DMARD) use among ...
Shenthuraan Tharmarajah   +6 more
wiley   +1 more source

The Pandemic Influenza Preparedness (PIP) Framework: strengthening laboratory and surveillance capacities in the Western Pacific Region, 2014–2017

open access: yesWestern Pacific Surveillance and Response, 2020
The Pandemic Influenza Preparedness (PIP) Framework Partnership Contribution Scheme has enabled countries to further strengthen their preparedness capacities in the areas of laboratory and surveillance, burden of disease estimation, regulatory capacity ...
Hitesh Chugh   +5 more
doaj   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

open access: yesAdvanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley   +12 more
wiley   +1 more source

COVID-19 and the climate-energy nexus [PDF]

open access: yes, 2020
Analysing the COVID-19 pandemic’s impact on the climate-energy nexus, raises three important questions. First, what does this global health and economic crisis mean for the future of fossil fuels, particularly oil?
Blondeel, Mathieu
core   +1 more source

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