CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham +8 more
wiley +1 more source
Coronavirus and the Heterogenesis of Ends: Underpinning the Ecological and Health Catastrophe is a Political Crisis [PDF]
The coronavirus catastrophe that we are experiencing is first of all the result of an ecological catastrophe, but its underlying fundamental cause is the political crisis that our democracies are living.
Bergandi, Donato
core
Chicken Pulmonary MicroRNAs Targeting the PB2 (Segment 1) of Avian Influenza Virus
The PB2 segment of H5N1 is essential for replication and host adaptation. We screened 200 miRNAs and identified five (gga‐miR‐17‐3p, gga‐miR‐29a‐5p, gga‐miR‐1718, gga‐miR‐16c‐5p, and gga‐miR‐1744‐5p) using thermodynamic stability of heteroduplex, seed sequence complementarity, conservation, and accessibility, offering insights into host antiviral ...
Akanksha Choudhary +7 more
wiley +1 more source
Children 'in need of care' or in need of cash? Questioning social security provisions for orphans in the context of the South African AIDS pandemic [PDF]
Joint working paper of the Children's Institute and Centre for Actuarial Research, University of Cape ...
Meintjes, Helen +3 more
core
Trends and Current Situation of China's Meat Sector
ABSTRACT As the world's largest meat producer, consumer, and importer, China's meat sector has undergone profound transformation over the past decade, driven by biological crises (e.g., African Swine Fever), environmental policies, and global market integration. This study analyzes the sector's production restructuring, consumption diversification, and
Zengyong Zhu
wiley +1 more source
Neglected Dimensions of Global Security: The Global Health Risk Framework Commission [PDF]
The world has experienced global health crises ranging from novel influenzas (H5N1 and H1N1) and coronaviruses (SARS and MERS) to the Ebola and Zika viruses.
Gostin, Lawrence O. +2 more
core +1 more source
The upcoming New Pact on Migration and Asylum: Will it be up to the challenge? EPC Discussion Paper 29 April 2020 [PDF]
A courageous and ambitious New Pact on Migration and Asylum is one that strengthens the right to asylum; sets the conditions for more equal relationships with third countries when it comes to managing migration; and puts forward a mechanism that can ...
Diez, Olivia Sundberg +1 more
core
Follicle Stimulating Hormone in Cattle Breeding: Fundamentals, Innovations, and Scope
FSH is crucial in cattle reproduction, with exogenous administration enhancing breeding and embryo production. Recombinant FSH offers advantages over pituitary‐extracted variants, including fewer injections, reduced stress, and safer production. These innovations improve breeding efficiency, optimize reproductive outcomes, and contribute to sustainable
Muhammad Shahzad +7 more
wiley +1 more source
Body donor programs in Australia and New Zealand: Current status and future opportunities
Abstract Body donation is critical to anatomy study in Australia and New Zealand. Annually, more than 10,000 students, anatomists, researchers, and clinicians access tissue donated by local consented donors through university‐based body donation programs. However, little research has been published about their operations.
Rebekah A. Jenkin, Kevin A. Keay
wiley +1 more source
Augmented reality for teaching undergraduate human anatomy: An educators' perspective
Abstract The purpose of this study was to explore the perspectives of Australian educators on using augmented reality (AR) as a method for learning human anatomy in the undergraduate health sciences. This will determine the current value of AR and guide future research and development. This prospective qualitative study used a mixed‐methods approach to
Ally Williams +2 more
wiley +1 more source

