Results 171 to 180 of about 649,762 (351)

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

Advanced Therapeutics, EarlyView.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack, Urszula Orzeł, Anja Schlör, Sourabh Mehta, Anandi Krishnan, Slawomir Filipek, Rushika Patel, Madhvi Joshi, Markus Hoffmann, Stefan Pöhlmann, Chaitanya Joshi, Dorian Liepmann, Ramasamy Paulmurugan, Venkatesan Renugopalakrishnan   +13 more
wiley   +1 more source

An Assessment of Covid-19 Pandemic Impact on Indonesian Tourism Sector

, 2021
Muhammad Eko Atmojo, Helen Dian Fridayani   +1 more
openalex   +2 more sources

A review of Cameroonian medicinal plants with potentials for the management of the COVID-19 pandemic [PDF]

, 2021
Evariste Fongnzossie Fedoung, Achille Bernard Biwôlé, Christine Fernande Nyangono Biyegue, Marlène Ngansop Tounkam, Patrick Akono Ntonga, Véronique Priscille Nguiamba, Damien Marie Essono, Preasious Forbi Funwi, Calvin Tonga, Guy Merlin Nguenang, V. Kemeuze, Dénis Sonwa, Nolé Tsabang, Isabelle Sandrine Bouelet, Zra Tize, Alexandre Teplaira Boum, Marie Caroline Momo Solefack, Jean Lagarde Betti, Achille Nouga Bissoué, Léopold Gustave Lehman, Pierre Marie Mapongmetsem, Léandre Nneme Nneme, Rosalie Annie Ngono Ngane, Jeanne Ngogang Yonkeu   +23 more
openalex   +1 more source

The pandemic present [PDF]

Social Anthropology, 2020
Whitacre, Ryan P., Buchbinder, Liza Stuart, Holmes, Seth M.   +2 more
openaire   +4 more sources

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Computational Design and Glycoengineering of Interferon‐Lambda for Nasal Prophylaxis Against Respiratory Viruses

Advanced Science, EarlyView.
This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun, Seungju Yang, Jae Hyuk Kwon, Luiz Felipe Vecchietti, Ji Hyun Choi, Mi‐ra Choi, Keun Bon Ku, Hyun‐Joo Ro, Kyun‐Do Kim, Meeyoung Cha, Hyun Jung Chung, Ji Eun Oh, Ho Min Kim   +12 more
wiley   +1 more source

A Meta-Analysis of the Association between Gender and Protective Behaviors in Response to Respiratory Epidemics and Pandemics

, 2016
Kelly R. Moran, Sara Y. Del Valle
openalex   +2 more sources

Trajectories of adolescent perceived stress and symptoms of depression and anxiety during the COVID-19 pandemic [PDF]

, 2022
Amanda W. G. van Loon, Hanneke E. Creemers, Simone Vogelaar, Nadira Saab, Anne C. Miers, P. Michiel Westenberg, Jessica J. Asscher   +6 more
openalex   +1 more source

An Aptamer‐Based EXACT Anticoagulant as a Sustainable, Animal‐Free Alternative to Unfractionated Heparin

Advanced Science, EarlyView.
By simply conjugating thrombin's active‐site inhibitor, dabigatran, with an exosite inhibitor, aptamer HD1, the resulting EXosite‐ACTive site (EXACT) inhibitors show two orders of magnitude higher potency and selectivity via synergistic binding, while maintaining the aptamer's antidote‐reversible trait, yielding a potential substitute for the animal ...
Haixiang Yu, George Pitoc, Manqi Zhang, Jeffrey Clancy, James Frederiksen, Amy Yan, Samuel Francis, Rebecca Sullenger, Rachel Rempel, Susannah Gammell, Jillian Caiazzi, Bruce A. Sullenger   +11 more
wiley   +1 more source

Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections

Advanced Science, EarlyView.
This review highlights the dynamic plasticity of macrophages during pulmonary infections and proposes an integrative framework defining six functional subtypes: Inflam‐Ms, Hub‐Ms, Reg‐Ms, Prolif‐Ms, Memory‐Ms, and Senesc‐Ms. Single‐cell omics delineate their distinct roles in homeostasis and infection, refining our understanding of macrophage ...
Zhaoheng Lin, Yuxiao Zheng, Yu Zhong, Hongyan Wang   +3 more
wiley   +1 more source