Results 51 to 60 of about 5,691,833 (269)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Chinese Journal of Population, Resources and EnvironmentA country’s ability to create complex goods and diversify its lines of products is essential for addressing all types of vulnerabilities. Quantifying a country’s vulnerability to extreme climatic events, such as droughts, superstorms, and other natural ...
Jabbar Ul-Haq +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Abstract This study examines the nexus between financial deepening and inclusive growth in West Africa using balanced annual panel data for 15 countries over the period 2000–2023. Inclusive growth is measured using a composite index generated through Principal Component Analysis (PCA), following the UNCTAD (2022) multidimensional ...
Oluwatoba Oyedele Adeniwura +1 more
openaire +1 more source
Journal of Business and TechnologyThe introduction of sustainability practices into sustainable business growth model remains a pressing concern, despite the emergence of sustainability disclosure being a critical tool for communicating firm’s commitment to sustainable practices. More so, sustainability disclosures vary significantly across developing economies like Nigeria where ...
Abdulkadri Toyin Alabi +2 more
openaire +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Cogent Economics & FinanceThe persistent global risks make the situation more challenging for the economies to show progression in economic growth. A well-functioning derivative market makes it feasible for firms to share risk effectively by means of financial development which ...
Wajid Shakeel Ahmed, Faheem Aslam
doaj +1 more source