Results 231 to 240 of about 3,038,457 (311)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Declining centromere strength compromises meiotic chromosome segregation in aging oocytes. [PDF]

J Cell Biol
Lemonnier T, Dumont M, Leem J, Khan A, Yazdkhasti H, Zimyanin V, Khutsaidze A, Redemann S, Fachinetti D, Mogessie B.   +9 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Acrolein target-linked toxicological perturbation and tumor-immune microenvironment heterogeneity in colorectal cancer. [PDF]

Front Cardiovasc Med
Cheng G, Shan L, Shi W, Liu X, Tao X, Han J.   +5 more
europepmc   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

American Epilepsy Society/Congress of Neurological Surgeons Epilepsy Surgery Clinical Practice Guideline. [PDF]

Epilepsy Curr
Jobst BC, Bergey G, Roldán-Benítez YM, Hopp JL, F Bauer D, Price A, Strickland SL, Bernat JL, Busch RM, Engel J, Gloss D, Husain AM, McGovern RA, McKhann GM, Nordli DR, Rolston JD, Shane R, Spencer D, Weiner HL, Nasif MB, Duda T, Eid A, Ghandour D, Hart S, Kesserwan M, Martyniuk A, Lannon M, Saber GT, Saouda C, Sharma S, Vinarsky V, J Darzi A, Gonzalez-Martinez J.   +32 more
europepmc   +1 more source

Glioblastoma immune landscape remodeling following treatment with CD70-targeted CAR-T cells. [PDF]

Oncoimmunology
Kourtesakis A, Agardy DA, Tejido Dierssen C, Hai L, Hoffmann DCF, Mussnig N, Sinn R, Fischer M, Schacht A, Breckwoldt M, Bunse L, Sauer T, Platten M, Wick W, Kessler T.   +14 more
europepmc   +1 more source